现代医药卫生2025，Vol.41Issue(10)：2291-2295,5.DOI:10.3969/j.issn.1009-5519.2025.10.007
膀胱癌患者ADC联合PD-1抑制剂新辅助治疗期间综合护理干预的效果
The effect of comprehensive nursing intervention during neoadjuvant treatment of ADC combined with PD-1 inhibitor in patients with bladder cancer
李莉萍 1蒋燕 1石越 1樊静1
作者信息
- 1. 重庆医科大学附属第一医院泌尿外科,重庆 400016
- 折叠
摘要
Abstract
Objective To explore the application effect of comprehensive nursing intervention on pa-tients with bladder cancer undergoing neoadjuvant treatment with antibody-drug conjugates(ADC)combined with programmed death receptor 1(PD-1)inhibitors.Methods A total of 42 patients with bladder cancer ad-mitted to the hospital from April 2022 to January 2024 were randomly divided into control group and observa-tion group,with 21 cases in each group.The control group received routine intervention,while the observation group received comprehensive nursing intervention based on intensified health education,psychological nursing and life nursing.The self-rating anxiety scale(SAS),self-rating depression scale(SDS),European quality of life core questionnaire(EORTC-QLQ-C30)and short fatigue assessment scale(BFI)were used to compare and analyze the mental health,quality of life and cancer-related fatigue before and after intervention in the two groups.Results After intervention,the scores of SAS and SDS in the observation group were lower than those in the control group,the scores of EORTC-QLQ-C30 in each dimension were higher than those in the control group,and the severity of cancer-related fatigue was lighter than that in the control group,with statis-tically significant differences(P<0.05).Conclusion The application of comprehensive nursing intervention strategy in the neoadjuvant treatment of bladder cancer patients with ADC combined with PD-1 inhibitor can promote their psychological rehabilitation,improve their quality of life and reduce cancer-related fatigue.关键词
综合护理干预/膀胱癌/新辅助治疗Key words
Comprehensive nursing intervention/Bladder cancer/Neoadjuvant treatment分类
医药卫生引用本文复制引用
李莉萍,蒋燕,石越,樊静..膀胱癌患者ADC联合PD-1抑制剂新辅助治疗期间综合护理干预的效果[J].现代医药卫生,2025,41(10):2291-2295,5.
