应用化学2025，Vol.42Issue(10)：1349-1360,12.DOI:10.19894/j.issn.1000-0518.250063
抗菌、抗氧化的多糖基止血海绵,用于鼻腔填塞和止血
Antibacterial,Antioxidant Polysaccharide-Based Hemostatic Sponge for Nasal Tamponade and Hemostasis
摘要
Abstract
Commercially available nasal hemostatic sponges suffer from inefficient hemostasis,non-degradability,and wound infection.Therefore,in order to respond to the market and clinical needs,it is particularly important to develop nasal hemostatic sponges with degradability,procoagulant,antimicrobial and antioxidant properties.Protocatechuic aldehyde(PA)and iron ion(Fe3+)produce the complex PA@Fe,which has antimicrobial,coagulation-promoting,and reactive oxygen species-clearing capabilities.In this regard,the basic sponge skeleton was composed of two varieties of polysaccharide hydrazide sodium alginate(SA-ADH)and sodium hyaluronate oxide(OHA),with varying concentrations of PA@Fe.By creating a cross-linked network with Schiff base connections inside the nasal cavity,a hemostatic sponge with antibacterial and antioxidant qualities was created to encourage coagulation.Using scanning electron microscopy(SEM)and Fourier transform infrared spectroscopy(FT-IR)to evaluate of the sponge's surface shape and functional groups while experimenting with the addition of various contents of PA@Fe the effect on the sponge's coagulation-promoting capacity,antimicrobial qualities,compressive strength,and capacity to scavenge reactive oxygen species.The sponge's mechanical qualities improved by 31.3%as a result of the content of PA@Fe increase.Furthermore,up to 62.4%of reactive oxygen species can be eliminated by the SO-PA@Fe sponge,and it has up to 97%antibacterial activity against Escherichia coli and Staphylococcus aureus.In contrast to gelatin hemostatic sponges that are sold commercially,SO-PA@Fe sponge absorbs blood twice as quickly.In summary,SO-PA@Fe sponge exhibits excellent coagulation,reactive oxygen species scavenging,and antibacterial properties,providing a new strategy for postoperative hemostasis and repair of sinusitis.关键词
鼻腔止血/多糖基海绵/原儿茶醛/铁离子/席夫碱键Key words
Nasal hemostasis/Polysaccharide based sponge/Protocatechuic aldehyde/Iron ions/Schiff base bond分类
化学化工引用本文复制引用
孙丽宇,郭传宇,陈美霖,王皓正,石强..抗菌、抗氧化的多糖基止血海绵,用于鼻腔填塞和止血[J].应用化学,2025,42(10):1349-1360,12.基金项目
国家自然科学基金(Nos.5206113520,51973222)、吉林省科学技术发展计划(Nos.20220401088YY)和长春市科学技术发展计划(No.24GXYSZ19)资助Supported by the National Natural Science Foundation of China(Nos.52061135202,51973222),Jilin Provincial Scientific and Technological Development Program(Nos.20220401088YY)and Changchun Scientific and Technological Development Program(No.24GXYSZZ19) （Nos.5206113520,51973222）
