应用化学2025，Vol.42Issue(10)：1375-1385,11.DOI:10.19894/j.issn.1000-0518.250083
基于仿生金属有机框架纳米酶介导的超灵敏心肌标志物光电化学传感器的构建及应用
Construction and Application Research of a Biomimetic MOF Nanozyme-Mediated Ultrasensitive Photoelectrochemical Sensor for Cardiac Biomarkers
雷玲钰 1苏靖昕 2周亚 1王耀1
作者信息
- 1. 晋中职业技术学院,晋中 030600
- 2. 朝阳师范学院生化工程系,朝阳 122000
- 折叠
摘要
Abstract
Cardiac troponin I(cTnI)is a highly sensitive and specific biomarker of myocardial injury,with high clinical value in the early diagnosis of cardiovascular diseases such as acute myocardial infarction(AMI).However,in the early stages of AMI,the concentration of cTnI in the serum is low and is influenced by other factors such as physiological changes and other diseases.It is urgent to develop biosensors with higher sensitivity and stronger anti-interference ability to improve the accuracy and reliability of early diagnosis.Based on this,this article constructs a novel and simple photoelectrochemical(PEC)biosensor,which utilizes a biomimetic metal organic framework(MOF)nanoenzyme catalyzed precipitation strategy to achieve highly sensitive detection of cTnI in human serum.The experimental results indicate that the detection range of cTnI is 0.1 pg/mL to 100 ng/mL,with a detection limit of 11.9 fg/mL.The myocardial biomarker photoelectrochemical sensor based on biomimetic MOF nanoenzyme has high sensitivity,low detection limit,wide linear response range,good selectivity and high stability.It can be used for early detection of cTnI,a marker of acute myocardial infarction,and is expected to achieve early diagnosis and treatment detection of acute myocardial infarction.关键词
金属有机框架纳米酶/光电化学免疫分析/生物催化沉淀/心肌肌钙蛋白Key words
Metal organic frameworks nanozyme/Photoelectrochemical immunoassay/Biocatalytic precipitation/Cardiac troponin I分类
化学化工引用本文复制引用
雷玲钰,苏靖昕,周亚,王耀..基于仿生金属有机框架纳米酶介导的超灵敏心肌标志物光电化学传感器的构建及应用[J].应用化学,2025,42(10):1375-1385,11.
