应用化学2025，Vol.42Issue(10)：1386-1396,中插4-中插10,18.DOI:10.19894/j.issn.1000-0518.240416
基于能量代谢的半夏泻心汤辛开、苦降组寒热属性及配伍意义
Nature of Cold and Heat and the Meaning of Compounding Within the Acrid Opening and Bitter Downbearing Groups of Banxia Xiexin Decoction Based on Energy Metabolism
摘要
Abstract
In order to reveal the effects of Acrid Opening and Bitter Downbearing groups of Banxia Xiexin Decoction on energy metabolism in rats before and after compatibility,and thereby exploring the changes in cold and hot properties after compounding.We established a rat model of heat syndrome through intragastric administration of Euthyrox(120 µg/kg)for a total of 15 days,monitoring alterations in physiological parameters(body mass,rectal temperature)throughout the treatment period,and assessed the hot plate reaction threshold of the rats following the final drug administration.Ultra high-performance liquid chromatography-mass spectrometry(UPLC-MS)was employed to analyze the content of energy metabolites in rat liver tissue.The results showed that compared with the model group,Huangqin(Scutellariae Radix),Huanglian(Coptidis Rhizoma),single decoction combination of Huangqin-Huanglian(or combined decoction),single decoction combination of Acrid Opening and Bitter Downbearing(or combined decoction),and four flavors single fried combination group could alleviate the signs of heat evidence,prolong the threshold of the hot plate reaction and inhibit energy metabolism in varying degrees.While the group of Banxia(Pinelliae Rhizoma),Ganjiang(Zingiberis Rhizoma),and single decoction combination of Banxia-Ganjiang(or combined decoction)could maintain the signs of heat evidence,reduce the threshold of the hot plate reaction and promote energy metabolism.Compared with the blank group,Huangqin,Huanglian,and single decoction combination of Huangqin-Huanglian(or combined Decoction)group decreased the rectal temperature and prolonged the threshold of hot plate reaction.While single decoction combination of Acrid Opening and Bitter Downbearing(or combined Decoction),and four flavors single fried combination group did not have any significant changes.This indicates that Huangqin,Huanglian and the two herbs showed cold property after single decoction or combined decoction;Banxia,Ganjiang and the two herbs showed hot property after single decoction or combined decoction;and the group of Acrid Opening and Bitter Downbearing tended to be slightly cold after combined decoction,thus exerting the efficacy of"regulating the cold and heat".In addition,the mode of decoction does not change the heat and cold properties of the drugs after combination,but it can affect the intensity of heat and cold after combination.关键词
半夏泻心汤/辛开苦降/中药药性/能量代谢Key words
Banxia Xiexin Decoction/Acrid Opening and Bitter Downbearing/Herbal medicinal properties/Energy metabolism分类
化学化工引用本文复制引用
王茂旭,赵跃刚,王俪颖,施威,刘祎男,邱智东,董雪莲..基于能量代谢的半夏泻心汤辛开、苦降组寒热属性及配伍意义[J].应用化学,2025,42(10):1386-1396,中插4-中插10,18.基金项目
吉林省科技发展计划项目(No.20220204002YY)资助Supported by Jilin Province Science and Technology Development Plan(No.20220204002YY) （No.20220204002YY）
