中国临床医学2025，Vol.32Issue(5)：865-872,8.DOI:10.12025/j.issn.1008-6358.2025.20241143
严重过敏反应的研究进展
Research progress of anaphylaxis
摘要
Abstract
The incidence of anaphylaxis has been on the rise in recent years.Drugs and foods are main triggers,and individuals in different regions and age groups have different characteristics.Its pathogenesis includes immune(IgE-mediated and non-IgE-mediated)factors,non-immune factors and idiopathic ones.The clinical manifestations are symptoms and signs of the skin and mucosa,and respiratory,circulatory,digestive,and nervous systems.There is still a lack of laboratory test indices with high sensitivity and specificity to diagnose anaphylaxis.Adrenaline intramuscular injection is the first-line treatment for anaphylaxis,but its usage during emergencies is unsatisfactory.Glucocorticoids are most frequently used in anaphylaxis,but there is controversy over whether they are beneficial.Currently,high-quality clinical cohort studies are needed to provide solid evidence for the epidemiology,diagnosis and treatment of anaphylaxis.This article reviews the research progress on anaphylaxis,aiming to enhance the understanding of anaphylaxis among medical staff.关键词
严重过敏反应/流行病学/诱因/治疗Key words
anaphylaxis/epidemiology/trigger/treatment分类
医药卫生引用本文复制引用
曾海銮,叶伶,金美玲..严重过敏反应的研究进展[J].中国临床医学,2025,32(5):865-872,8.基金项目
复旦大学附属中山医院"卓越住院医师"临床博士后项目(2023ZYYS-003).Supported by Outstanding Resident Clinical Postdoctoral Program of Zhongshan Hospital,Fudan University(2023ZYYS-003). （2023ZYYS-003）
