中国临床医学2025，Vol.32Issue(5)：885-890,6.DOI:10.12025/j.issn.1008-6358.2025.20250475
美泊利珠单抗治疗嗜酸性肉芽肿性血管炎致肝损伤1例报告
Liver injury induced by mepolizumab in treatment of eosinophilic granulomatosis with polyangiitis:a case report
摘要
Abstract
A 52-year-old female patient was diagnosed with eosinophilic granulomatosis with polyangiitis(EGPA),asthma and allergic rhinitis and was treated with mepolizumab(100 mg,once every 4 weeks).Three days after the second administration,the patient developed dark yellow urine,and abnormal liver function indicators were found on day 6 after administration.Laboratory tests showed total bilirubin(TBIL)of 22 μmol/L,direct bilirubin(DBIL)of 14.9 μmol/L,alanine aminotransferase(ALT)of 461 U/L,aspartate aminotransferase(AST)of 129 U/L,and alkaline phosphatase(ALP)of 296 U/L.After a comprehensive assessment,it was considered that mepolizumab may caused liver injury in the patient.Magnesium isoglycyrrhizinate,glutathione,and ursodeoxycholic acid were used for liver protection.Five days later,the urine color became lighter and liver function indicators improved(TBIL 17.4 μmol/L,DBIL 9.8 μmol/L,ALT 214 U/L,AST 85 U/L,ALP 226 U/L).After about 2 weeks of continued liver protection treatment,liver function returned to normal.Mepolizumab treatment was suspended and during the follow-up for about half a year,the patient did not experience liver function abnormalities or other discomforts again.关键词
美泊利珠单抗/嗜酸性肉芽肿性血管炎/药物性肝损伤/药品不良反应Key words
mepolizumab/eosinophilic granulomatosis with polyangiitis/drug-induced liver injury/adverse drug reaction分类
医药卫生引用本文复制引用
李亚前,李晓宇,金美玲,叶晓芬..美泊利珠单抗治疗嗜酸性肉芽肿性血管炎致肝损伤1例报告[J].中国临床医学,2025,32(5):885-890,6.基金项目
国家自然科学基金(82270028).Supported by National Natural Science Foundation of China(82270028). （82270028）
