中国实用儿科杂志2025，Vol.40Issue(9)：746-751,6.DOI:10.19538/j.ek2025090608
儿童系统性红斑狼疮的诊断与治疗
Diagnosis and treatment of childhood-onset systemic lupus erythematosus
摘要
Abstract
Childhood-onset systemic lupus erythematosus(cSLE)is a chronic autoimmune disease characterized by acuter onset,severer clinical manifestations,and poorer prognosis than those of adult-onset SLE.Early diagnosis and standardized treatment are crucial for improving outcomes.Currently,the diagnosis primarily relies on the 2012 SLICC and 2019 EULAR/ACR criteria,which were developed based on adult populations.Although these criteria perform well in the diagnosis of cSLE,they still have limitations in clinical practice.In the treatment a"treat-to-target"goal is emphasized and individualized treatment is conducted.Conventional therapy primarily consists of glucocorticoids combined with immunosuppressants,while the use of biologics can help reduce steroid use,lower disease activity,and decrease disease recurrences.The 2024 ACR guidelines recommend multitarget combination therapy for proliferative lupus nephritis,which shows promising results in adult patients.However,its actual efficacy and long-term safety in pediatric populations still require further validation.关键词
系统性红斑狼疮/靶向治疗/个体化治疗Key words
systemic lupus erythematosus/targeted therapy/individualized treatment分类
医药卫生引用本文复制引用
张育迪,沈田,吴小川..儿童系统性红斑狼疮的诊断与治疗[J].中国实用儿科杂志,2025,40(9):746-751,6.基金项目
国家自然科学基金专项项目(32441100) （32441100）
湖南省自然科学基金项目(2025JJ60709) （2025JJ60709）
