中国药科大学学报2025，Vol.56Issue(5)：539-547,9.DOI:10.11665/j.issn.1000-5048.2024101402
肝脏器官芯片在成药性评价中的应用进展
Application of liver-on-a-chip in druggability evaluation
摘要
Abstract
Druggability evaluation is one of the core processes in new drug development,yet the inaccuracy and high cost of existing in vitro liver models have been a major technical bottleneck,leading to an increasing demand from the pharmaceutical industry for reliable in vitro liver models to enhance the efficiency of new drug research and development.Traditional animal models and in vitro 2D culture models have their limitations in simulating in vivo physiological and pathological conditions,making it challenging to accurately predict drug efficacy and safety.With the advancement of microfluidic technology,in vitro cell culture,and biosensor technology,liver-on-a-chip(LOC)has garnered increasing attention in the field of new drug development in recent years,and is expected to become a powerful tool for addressing the challenges in druggability evaluation.While introducing the construction technology of LOC,this article mainly summarizes the research and application of existing LOC from the perspectives of disease model construction,drug metabolism research,and drug safety evaluation.Furthermore,it analyzes the role of LOC in druggability evaluation and discusses the current challenges and prospects in this field.关键词
肝脏器官芯片/类器官/成药性评价/体外模型/微流控Key words
liver-on-a-chip/organoids/druggability evaluation/in-vitro model/microfluidics分类
医药卫生引用本文复制引用
涂远博,徐晨,王译羽,王尧龙,张峻颖,吴春勇..肝脏器官芯片在成药性评价中的应用进展[J].中国药科大学学报,2025,56(5):539-547,9.基金项目
This study was supported by Yunnan Chunyong Wu Expert Workstation Project(202305AF150034) 云南省吴春勇专家工作站资助项目(202305AF150034) （202305AF150034）
