中国药科大学学报2025，Vol.56Issue(5)：613-623,11.DOI:10.11665/j.issn.1000-5048.2025031402
基于网络药理学研究藏茴香入血成分抗白癜风的作用机制
Anti-vitiligo mechanism of blood-absorbed components of Carum carvi L.based on network pharmacology
摘要
Abstract
To investigate the pharmacological substances basis and anti-vitiligo mechanism of Carum carvi L.(caraway)fruits,chemical and blood-absorbed components were identified using mass spectrometry combined with literature study and database analysis.A"blood-absorbed components-target genes-pathways"network was constructed through network pharmacology.The pharmacological effects of Carum carvi L.extract and its key blood-absorbed component,acacetin,were validated in vitro.72 chemical components were identified in the extract,with 11 prototype blood-absorbed components and 26 metabolites being detected in the plasma of SD rats.14 key active components and 24 key targets were predicted.In vitro experiments demonstrated that acacetin at 10 μmol/L exhibited melanogenesis-promoting and tyrosinase-activating effects compared with the positive control,significantly upregulating the expression of microphthalmia-associated transcription factor(MITF)and tyrosinase(tyrosinase,TYR).This study comprehensively analyzes the chemical and blood-absorbed components of Carum carvi L.and elucidates its pharmacological substances basis,which provides a theoretical foundation for the anti-vitiligo effects of acacetin.关键词
藏茴香/UPLC-Q-Exactive-Orbitrap-HRMS/网络药理学/促黑活性/抗白癜风/刺槐素Key words
Carum carvi L./UPLC-Q-Exactive Orbitrap-HRMS/network pharmacology/melanogenic activity/anti-vitiligo/acacetin分类
医药卫生引用本文复制引用
谭玥玥,热依木古丽·阿布都拉,臧登,李淑萍,夏依丹·阿布力米提,信学雷,贺飞..基于网络药理学研究藏茴香入血成分抗白癜风的作用机制[J].中国药科大学学报,2025,56(5):613-623,11.基金项目
新疆维吾尔自治区天山英才培养计划项目(2022TSYCCX0023) （2022TSYCCX0023）
新疆维吾尔自治区自然科学基金项目(2022D01E94,2023D01A05,2022D01B208) （2022D01E94,2023D01A05,2022D01B208）
新疆维吾尔自治区重点研发项目(2022B03007-3) This study was supported by Tianshan Talent Training Program of Xinjiang Uygur Autonomous Region(2022TSYCCX0023) （2022B03007-3）
the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01E94,2023D01A05,2022D01B208) （2022D01E94,2023D01A05,2022D01B208）
and the Key Research and Development Project of Xinjiang Uygur Autonomous Region(2022B03007-3) （2022B03007-3）
