中国药科大学学报2025，Vol.56Issue(5)：624-633,10.DOI:10.11665/j.issn.1000-5048.2025040102
基于网络药理学探究藏药佐汤卡擦丸治疗高血压的药理作用机制
Pharmacological mechanism of Tibetan medicine Zuotangkaca pills for the treatment of hypertension based on network pharmacology
摘要
Abstract
The mechanism of Tibetan medicine Zuotangkaca pills(ZTKCW)for the treatment of hypertension was explored by network pharmacology and in vivo experiments.68 active ingredients of ZTKCW and 518 drug-disease targets were screened by network pharmacology.Eight core components of ZTKCW(vasicolinone,luteolin,(-)-isocorypalmine,esculetin,liquiritigenin,etc.)and eight key targets(AKT1,TNF,IL6,and STAT3,etc.)were screened by network topology analysis.KEGG enrichment analysis showed that the core targets were mainly enriched in lipids and atherosclerosis,JAK/STAT,and inflammation-related pathways.An in vivo experiment was conducted using spontaneously hypertensive rats(SHR),which were gavaged with ZTKCW at doses of 0.41,0.82,and 1.64 g/kg for 12 weeks,respectively.The results showed that ZTKCW at a dose of 1.64 g/kg significantly reduced both systolic and diastolic pressure in SHR rats and decreased the phosphorylation levels of AKT1,PI3K,STAT3,and JAK2 in the thoracic aorta and heart tissues.This study demonstrates that ZTKCW may exert its antihypertensive effects through PI3K/AKT and JAK2/STAT3 pathways,providing some insights and a theoretical basis for the use of ZTKCW in hypertension.关键词
高血压/佐汤卡擦丸/网络药理学/作用机制Key words
hypertension/ZTKCW/network pharmacology/mechanism分类
医药卫生引用本文复制引用
更桑,邹欣欣,白玛罗布,扎西道知,纪雪娇,多杰仁青,黄凤杰..基于网络药理学探究藏药佐汤卡擦丸治疗高血压的药理作用机制[J].中国药科大学学报,2025,56(5):624-633,10.基金项目
中央支持地方高校改革发展资金-西藏藏医药大学博士点培育项目(BSDJS-XKJS-24-02) This study was supported by the Central Funds for the Reform and Development of Local Universities and Colleges-Doctoral Incubation Programme of Tibetan Medicine University(BSDJS-XKJS-24-02) （BSDJS-XKJS-24-02）
