中国医学创新2025，Vol.22Issue(29)：25-29,5.DOI:10.3969/j.issn.1674-4985.2025.29.006
替罗非班联合替格瑞洛治疗急性心肌梗死PCI术后患者的效果观察
Observation on the Effect of Tirofiban Combined with Ticagrelor in the Treatment of Patients with Acute Myocardial Infarction Undergoing PCI
摘要
Abstract
Objective:To investigate the effects of Tirofiban combined with Ticagrelor on cardiac function and major adverse cardiovascular events in patients with acute myocardial infarction(AMI)undergoing percutaneous coronary intervention(PCI).Method:A retrospective analysis was conducted on 84 AMI patients who underwent PCI in Fengcheng People's Hospital from January 2021 to January 2024.They were divided into two groups according to different treatment methods.The control group(n=42)was treated with Ticagrelor,while the observation group(n=42)was treated with Tirofiban on this basis.The clinical efficacy,coronary blood flow indicators,cardiac function,serum inflammatory factors and the incidence of major adverse cardiovascular events were compared between the two groups.Result:The total effective rate of treatment in the observation group was 92.86%,which was higher than 76.19%in the control group(P<0.05).After treatment,the diastolic peak velocity(DPV),systolic peak velocity(SPV),coronary flow velocity reserve(CFVR),and left ventricular ejection fraction(LVEF)of the left anterior branch in the observation group were all higher than those in the control group;the left ventricular end-diastolic diameter(LVEDD),IL-6,TNF-α,and hs-CRP were all lower than those in the control group(P<0.05).The incidence of major adverse cardiovascular events in the observation group(4.76%)was lower than that in the control group(19.05%)(P<0.05).Conclusion:The treatment of AMI patients undergoing PCI with Tirofiban combined with Ticagrelor has achieved remarkable results.The coronary blood flow and cardiac function of the patients have been effectively improved,the inflammatory response has been effectively alleviated,and the incidence of major adverse cardiovascular events is relatively low.关键词
急性心肌梗死/经皮冠状动脉介入治疗/替罗非班/替格瑞洛/心功能/主要不良心血管事件Key words
Acute myocardial infarction/Percutaneous coronary intervention/Tirofiban/Ticagrelor/Heart function/Major adverse cardiovascular events引用本文复制引用
夏日辉,熊丹东,吴高祥..替罗非班联合替格瑞洛治疗急性心肌梗死PCI术后患者的效果观察[J].中国医学创新,2025,22(29):25-29,5.基金项目
江西省卫生健康委科技计划项目(SKJP220227566) （SKJP220227566）
