摘要
Abstract
Objective:To investigate the effect of the combination of Propranolol and Thiamazole on patients with hyperthyroidism.Method:A total of 86 hyperthyroidism patients admitted to Ganzhou People's Hospital from March 2022 to March 2024 were divided into two groups by random number table method.The control group(n=43)was treated with Thiamazole,and the observation group(n=43)was treated with Propranolol on the basis of control group.Both groups were treated for 3 months.The comparisons were performed on the clinical efficacy,glucose and lipid metabolism levels,calcium and phosphorus metabolism levels,thyroid function,and adverse reactions in both groups.Result:The observation group obtained higher total effective rate than that of the control group,with statistical difference(χ2=4.441,P=0.035).After treatment,the levels of TC,TG,LDL-C,blood phosphorus,FT4,and FT3 in the observation group were lower than those in the control group,while the levels of blood calcium and thyroid stimulating hormone(TSH)in the observation group were higher than those in the control group(P<0.05).After treatment,there were no statistically significant differences in 2 h postprandial glucose(2 h PG)and fasting plasma glucose(FPG)levels between the two groups(P>0.05).The incidence of adverse reactions was comparable between the two groups,with no statistically significant difference(P>0.05).Conclusion:The combination of Propranolol and Thiamazole has a definite therapeutic effect,it can regulate calcium and phosphorus metabolism levels,promote thyroid function improvement,and have a relatively small impact on glucose and lipid metabolism,does not increase the adverse reactions.关键词
甲状腺功能亢进症/甲巯咪唑/普萘洛尔/糖脂代谢/钙磷代谢Key words
Hyperthyroidism/Thiamazole/Propranolol/Glucose and lipid metabolism/Calcium and phosphorus metabolism
