中国中药杂志2025，Vol.50Issue(18)：5055-5068,14.DOI:10.19540/j.cnki.cjcmm.20250421.601
人肠道细菌CAZymes对中药多糖利用位点的研究进展
Research progress on polysaccharide utilization loci from traditional Chinese medicine by carbohydrate-active enzymes within human intestinal flora
摘要
Abstract
Polysaccharides are crucial bioactive components of traditional Chinese medicine(TCM).The bioavailability and health effects of traditional Chinese medicine(TCM)polysaccharides are fundamentally governed by the metabolism regulation of carbohydrate-active enzymes(CAZymes)within the human intestinal flora.This review systematically summarized the classification and functional distribution of CAZymes in intestinal flora,as well as the dynamic regulatory mechanisms by which their encoded polysaccharide utilization loci(PULs)recognize and degrade TCM polysaccharides.Through synergistic interactions between substrate-binding modules(CBMs)and catalytic domains,CAZymes precisely recognize glycosidic bond types and spatial conformations of polysaccharides and then convert these complex polysaccharides into oligosaccharides,short-chain fatty acids(SCFAs),and other metabolites.These metabolites subsequently influence host health via immune regulation,metabolic homeostasis,and intestinal barrier repair.Furthermore,the review proposed that future research should focus on elucidating three-dimensional structures of CAZymes-polysaccharide complexes,exploring cross-phylum cooperative metabolic mechanisms,and developing microbiota-directed TCM polysaccharide delivery systems.This work systematically elucidated the core mechanisms of gut CAZymes-mediated TCM polysaccharide metabolism,providing theoretical foundations for clarifying the pharmacodynamic material basis of TCM and advancing innovative drug development of TCM polysaccharides.关键词
肠道细菌/中药多糖/碳水化合物活性酶/多糖利用位点/拟杆菌Key words
intestinal flora/traditional Chinese medicine polysaccharide/carbohydrate-active enzyme/polysaccharide utilization locus/Bacteroides引用本文复制引用
郭龙明,白光剑,田馨,胡惠萍,王雅琪,陈少丹..人肠道细菌CAZymes对中药多糖利用位点的研究进展[J].中国中药杂志,2025,50(18):5055-5068,14.基金项目
国家自然科学基金面上项目(82373770) （82373770）
广东省自然科学基金青年提升项目(2023A1515030151) （2023A1515030151）
