中国中药杂志2025，Vol.50Issue(18)：5081-5089,9.DOI:10.19540/j.cnki.cjcmm.20250603.501
从心阴虚致肌萎缩论慢性心力衰竭骨骼肌萎缩发生机制及防治进展
Pathogenesis and therapeutic advances in skeletal muscle atrophy associated with chronic heart failure:a discussion from perspective of heart Yin deficiency
摘要
Abstract
Chronic heart failure(CHF)represents the terminal phase of severe cardiovascular diseases,with concomitant skeletal muscle atrophy significantly compromising patients' motor function and quality of life,as well as increasing risks of adverse clinical outcomes.Current therapeutic agents and interventions targeting CHF-associated muscle atrophy remain limited.Grounded in a holistic approach and syndrome differentiation,traditional Chinese medicine(TCM)offers unique advantages in managing CHF comorbidities.This review explored the pathological mechanisms underlying skeletal muscle atrophy in CHF through the lens of the"heart Yin deficiency"theory in TCM.A pathogenic triad was proposed,encompassing collateral malnutrition due to Yin deficiency,toxin-stasis interaction,and physical-mental exhaustion.The triad was examined in relation to modern biomedical mechanisms including neuroendocrine dysregulation,oxidative stress-inflammation,microcirculatory dysfunction,and protein metabolic imbalance,highlighting the central role of heart Yin deficiency in disease progression.From the therapeutic perspective of nourishing heart Yin,the multi-target effects of herbal compound formulae and acupuncture therapy in improving cardiac function and alleviating muscle atrophy were analyzed.This analysis aims to provide both theoretical foundations and practical guidance for the clinical management of CHF with skeletal muscle atrophy.关键词
心阴虚/慢性心力衰竭/骨骼肌萎缩/养阴Key words
heart Yin deficiency/chronic heart failure/skeletal muscle atrophy/Yin nourishment引用本文复制引用
李思静,鲁路,杨忠奇,倪世豪,李姿儒,张小娇,何星灵,陈嘉慧,董晓明,龙文杰,刘健红,廖慧丽..从心阴虚致肌萎缩论慢性心力衰竭骨骼肌萎缩发生机制及防治进展[J].中国中药杂志,2025,50(18):5081-5089,9.基金项目
国家自然科学基金项目(82374406) （82374406）
广州市重点研发计划项目(2024B03J1298) （2024B03J1298）
广州市科学技术局基础与应用基础研究项目(2025A03J3726) （2025A03J3726）
杨忠奇省名中医传承工作室项目(粤中医办函[2023]108号) （粤中医办函[2023]108号）
广东省中医药局科研项目(20241087,20241109) （20241087,20241109）
