中国中药杂志2025，Vol.50Issue(18)：5090-5097,8.DOI:10.19540/j.cnki.cjcmm.20250715.501
基于"胞宫干血"理论探析PI3K/Akt信号通路在宫腔粘连纤维化中的作用
Analysis of role of PI3K/Akt signaling pathway in intrauterine adhesion fibrosis based on theory of"dry blood in uterus"
摘要
Abstract
Intrauterine adhesion(IUA)is a disease of partial or total occlusion of the uterine cavity due to trauma-and(or)infection-caused partial or complete damage to the basal layer of the endometrium.IUA ranks as one of the major causes of menstrual disorder,infertility,or recurrent miscarriage,gravely menacing women's physical and mental health.At present,the pathological mechanism of IUA remains unclear.However,endometrial fibrosis is an acknowledged hypothesis.The phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway,as one of the significant signaling pathways involved in the pathological process of IUA,can partake in the fibrosis process by mediating inflammatory responses,oxidative stress responses,apoptosis,and autophagy.Regulating the PI3K/Akt signaling pathway to decelerate the fibrosis process might potentially be a viable therapeutic strategy for IUA.Traditional Chinese medicine(TCM)holds that deficiency,heat,and blood stasis represent the main pathological factors of IUA.The pathological characteristic of IUA is consistent with the pathogenesis of dry blood in TCM theory.Thus,dry blood can be considered a key pathological mechanism for the onset and development of IUA.Considering the unique physiological and pathological traits of the uterus,this study further proposed the TCM theory of"dry blood in uterus".Moreover,the endometrial fibrosis process mediated by the PI3K/Akt signaling pathway bears certain resemblances to the pathological process of IUA triggered by"dry blood in uterus".In light of this,this paper,for the first time,thoroughly analyzed the deep-seated connection between the PI3K/Akt signaling pathway and the pathogenesis of IUA fibrosis from the perspective of the TCM theory of"dry blood in uterus".The aim is to offer a theoretical basis and research direction for the treatment of IUA and relevant drug research.关键词
宫腔粘连/纤维化/"胞宫干血"/PI3K/Akt信号通路Key words
intrauterine adhesion/fibrosis/"dry blood in uterus"/PI3K/Akt signaling pathway引用本文复制引用
洪丹丹,左文婷,王海丹,赵玉芹,商婷婷,徐馨琪,翟奕菲,郭红玉..基于"胞宫干血"理论探析PI3K/Akt信号通路在宫腔粘连纤维化中的作用[J].中国中药杂志,2025,50(18):5090-5097,8.基金项目
江苏省中医药管理局青年项目(QN202211) （QN202211）
第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
国家中医临床研究基地开放课题(JD2023SZ07) （JD2023SZ07）
