中国中药杂志2025，Vol.50Issue(18)：5098-5110,13.DOI:10.19540/j.cnki.cjcmm.20250529.201
缺血性脑卒中线粒体损伤的关键靶点及中医药干预机制研究进展
Research advances in key mitochondrial injury targets and mechanisms of traditional Chinese medicine intervention in ischemic stroke
摘要
Abstract
Ischemic stroke is one of the most severe vascular diseases in the central nervous system,with its pathogenesis involving acute cerebrovascular occlusion leading to local cerebral ischemia and hypoxia,triggering complex pathophysiological cascading reactions.Mitochondrial dysfunction serves as the critical pathological foundation of disease progression,primarily manifesting as significantly enhanced oxidative stress,cellular metabolic disorders,abnormal apoptotic signal activation,amplified inflammatory cascades,and mitochondrial dynamic imbalance.The molecular mechanisms of mitochondrial injury involve multiple key signaling pathways:mitochondrial electron transport chain dysfunction generating substantial reactive oxygen species,calcium overload disrupting mitochondrial membrane potential,and mitochondrial dynamic imbalance leading to fragmentation-fusion disequilibrium.Studies have confirmed that from single herbal active ingredients to compound preparations and even acupuncture and moxibustion,traditional Chinese medicine(TCM)demonstrates multidimensional and multilevel synergistic neuroprotective effects.Focusing on the epidemiological trend of ischemic stroke with a rising incidence,this study delves into mitochondrial dysfunction,the core molecular pathological mechanism of disease occurrence and progression.By systematically elaborating on the multi-target and multi-mechanism intervention strategies of TCM in the neurological protection domain,this study reveals the complex molecular network of mitochondrial damage and highlights the unique therapeutic advantages of TCM in regulating mitochondrial membrane potential,inhibiting oxidative stress,optimizing energy metabolism,and reducing cellular apoptosis.It explores a novel molecular target system for treating ischemic stroke,offering a new theoretical foundation for integrative medicine research.关键词
缺血性脑卒中/线粒体损伤/中医药/综述Key words
ischemic stroke/mitochondrial injury/traditional Chinese medicine/review引用本文复制引用
欧昌泽,陈彬彬,刘新利,王红斌,谢湖,龙华君..缺血性脑卒中线粒体损伤的关键靶点及中医药干预机制研究进展[J].中国中药杂志,2025,50(18):5098-5110,13.基金项目
2022年全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
湖南省卫生健康委科研计划项目(C202303078160) （C202303078160）
