浙江大学学报（农业与生命科学版）2025，Vol.51Issue(5)：675-685,11.DOI:10.3785/j.issn.1008-9209.2025.04.271
跨透明带伪足:卵丘细胞-卵母细胞间的双向通信桥梁
Transzonal projections:a bidirectional communication bridge between cumulus cells and oocytes
摘要
Abstract
Transzonal projections(TZPs)are protrusions derived from the cytoplasm of cumulus cells,serving as unique dynamic connecting structures between mammalian cumulus cells and oocytes.As a key bridge for material transport and information exchange between cumulus cells and oocytes,TZPs play crucial roles in follicular development and oocyte maturation.TZPs support oocyte development by transporting metabolic substances such as pyruvic acid,mediate signal transduction to maintain meiotic arrest,and regulate granulosa cell differentiation to form a bidirectional communication network.The dynamic formation and function of TZPs are regulated by hormones,growth factors and other molecules,resulting in structural plasticity and functional diversity.This review summarizes the occurrence mechanism,structural heterogeneity and molecular regulatory network of TZPs,systematically analyzes the kinetic changes in TZPs and the regulatory principles of oocyte maturation mediated by TZPs,aiming to bridge the theoretical gap in communication between gonadal cells and germ cells,and provide a key theoretical basis for the optimization of the in vitro maturation system of oocytes and intervention strategies for ovarian dysfunction.关键词
跨透明带伪足/卵丘细胞/卵母细胞/卵泡发育Key words
transzonal projections/cumulus cells/oocytes/follicular development分类
生物科学引用本文复制引用
张爵顺,吕静,刘光宇,王一凡,Dmitry IL,江中良..跨透明带伪足:卵丘细胞-卵母细胞间的双向通信桥梁[J].浙江大学学报（农业与生命科学版）,2025,51(5):675-685,11.基金项目
国家重点研发计划项目(2024YFE0213400) （2024YFE0213400）
国家自然科学基金面上项目(32272880). （32272880）
