浙江大学学报（农业与生命科学版）2025，Vol.51Issue(5)：710-721,12.DOI:10.3785/j.issn.1008-9209.2025.06.191
牛胎盘早期发育研究进展
Research progress on early placental development in cattle
摘要
Abstract
Pregnancy loss is a key issue limiting the sustainable development of cattle breeding,with about 50%occurring in the early stages of embryonic development,while abnormal placental development is a significant cause of early pregnancy loss.The bovine placenta is a semi-invasive synepitheliochorial placenta,which has a unique pattern of trophoblast cell development and invasion that is closely related to placental development.Currently,most studies focus on placental morphology and function,and there is still a lack of systematic multi-omics integrated analysis on the mechanism of abnormal placental development and its correlation with pregnancy loss.This paper focuses on the early developmental biology of the bovine placenta;describes key biological events,such as chorioallantoic development,trophoblast cell differentiation and placentome formation;dissects the effects of genetics,assisted reproductive technology,disease and other factors on placental development;and provides an outlook on the research of spatial enhanced resolution omics-sequencing(Stereo-seq),single-cell RNA sequencing(scRNA-seq)and other cutting-edge technologies in bovine placenta,aiming to enhance the understanding of bovine placental development from a microscopic perspective,with the goal of promoting the high-quality development of cattle breeding.关键词
牛/胎盘发育/妊娠损失/组学技术Key words
cattle/placental development/pregnancy loss/omics technology分类
农业科技引用本文复制引用
林海威,胥栩,朱阁,戴鹏秀,王华南,陈晨..牛胎盘早期发育研究进展[J].浙江大学学报（农业与生命科学版）,2025,51(5):710-721,12.基金项目
国家自然科学基金项目(32373076) （32373076）
杭州城西科创大走廊创新发展专项(B231220.0005-46). （B231220.0005-46）
