浙江农林大学学报2025，Vol.42Issue(5)：922-933,12.DOI:10.11833/j.issn.2095-0756.20240567
菊花活性物质种类、合成途径与调控机制研究进展
Research progress on the types,biosynthetic pathways,and regulatory mechanisms of bioactive compounds in Chrysanthemum×morifolium
摘要
Abstract
Chrysanthemum×morifolium,a plant with a long history of ornamental,edible,and medicinal uses,contains bioactive compounds with multiple functions,such as anti-inflammatory,antioxidant,and anti-tumor properties.This article reviews the types and mechanisms of action of bioactive compounds in C.×morifolium,summarizes their biosynthetic pathways,and elucidates the regulatory mechanisms governing their synthesis.Chalcone synthase(CHS),chalcone isomerase(CHI),flavanone 3-hydroxylase(F3H),flavonoid 3'-hydroxylase(F3'H),flavone synthase(FNS),flavonol synthase(FLS),4-coumarate-CoA ligase(4CL),and UDP-glycosyltransferase(UGT)have been identified as key players in the synthesis of bioactive compounds.The biosynthesis is hierarchically regulated:transcription factor families such as MYB,bHLH,and AP2/ERF,modulate structural gene expression by binding to specific promoter elements.Additionally,miRNAs affect the synthesis of these compounds by targeting crucial structural genes and transcription factors.Although many researches have been conducted on flavonoid structure and biosynthesis in C.×morifolium,studies on the synthesis mechanism of chlorogenic acid,an important pharmacological component,remain limited and require further exploration.Clarifying the global regulatory network of bioactive compound biosynthesis and the molecular crosstalk between secondary metabolic pathways will be crucial for developing sustainable and efficient synthesis strategies for C.×morifolium active compounds,thereby advancing the development of the C.×morifolium industry.[Ch,5 fig.1 tab.81 ref.].关键词
菊花/活性物质/合成途径/调控机制Key words
Chrysanthemum×morifolium/bioactive compounds/biosynthetic pathways/regulatory mechanisms分类
农业科技引用本文复制引用
赵凡,黄国林,肖晓玲,刘洋,李卫东,唐桂梅..菊花活性物质种类、合成途径与调控机制研究进展[J].浙江农林大学学报,2025,42(5):922-933,12.基金项目
国家重点研发计划子项目(2024YFD1600903-3) （2024YFD1600903-3）
湖南省林业生态保护修复及发展专项资金项目(湘财资环指[2023]5号,湘财资环指[2024]3号) （湘财资环指[2023]5号,湘财资环指[2024]3号）
湖南省农业科技创新资金项目(2024CX30) （2024CX30）
