北京中医药大学学报2025，Vol.48Issue(10)：1413-1418,6.DOI:10.3969/j.issn.1006-2157.2025.10.010
从"清浊相干"与"肠-皮轴"辨治特应性皮炎
Managing atopic dermatitis through the perspectives of"clear-turbid interference"and the"gut-skin axis"
摘要
Abstract
Atopic dermatitis is a common chronic,relapsing,inflammatory skin disease;however,its pathogenesis remains unclear.The theory of"clear-turbid interference"originates from the Inner Canon of Yellow Emperor and refers to a pathological condition in which clear yang and turbid yin intermingle,and qi movement becomes disordered.This paper elucidates the theoretical connotation of"clear-turbid interference"and its core mechanism in triggering atopic dermatitis,as well as the role of the"gut-skin axis"in atopic dermatitis development.Internal dampness-turbidity and disharmony between ying and wei constitute the core pathological mechanisms linking clear-turbid interference to atopic dermatitis.Treatment for different stages and syndromes should be guided by syndrome differentiation.For example,for spleen deficiency with a dampness syndrome in subacute or chronic stages,Chushi Weiling Decoction may be used to fortify the spleen,eliminate dampness,lift the clear,and downbear the turbid.For patterns with prominent heat manifestations,such as dampness-heat immersion or heart fire with spleen deficiency,bitter-cold dampness-drying herbs can be added on this basis.For wind-dampness-heat accumulation in the acute stage,Mahuang Lianyao Chixiaodou Decoction can be used to release the exterior,expel pathogens,and harmonize ying and wei.In cases of spleen deficiency with blood dryness or liver-kidney insufficiency during the chronic stage,in addition to nourishing yin to moisten the skin and tonifying the liver-kidney,wind-medicinals should also be employed to open the sweat pores and promote qi movement.These approaches restore the physiological state without clear-turbid interference while regulating intestinal flora,providing new approaches and perspectives for integrating traditional Chinese and Western medicine in treating atopic dermatitis.关键词
特应性皮炎/肠-皮轴/清浊相干/肠道菌群Key words
atopic dermatitis/gut-skin axis/clear-turbid interference/intestinal flora分类
中医学引用本文复制引用
赵圣轩,汤阳,李荣欣,崔婉彤,郑丰杰..从"清浊相干"与"肠-皮轴"辨治特应性皮炎[J].北京中医药大学学报,2025,48(10):1413-1418,6.基金项目
国家自然科学基金项目(No.82374321) （No.82374321）
北京中医药大学"揭榜挂帅"项目(No.2023-JYB-JBZD-035) National Natural Science Foundation of China(No.82374321) （No.2023-JYB-JBZD-035）
