福建师范大学学报（自然科学版）2025，Vol.41Issue(6)：87-94,8.DOI:10.12046/j.issn.1000-5277.2025090018
新型STING激动剂及递送策略的研究进展
Research Advances in Novel STING Agonists and Their Delivery Strategies
摘要
Abstract
The STING pathway is a critical signaling pathway in the innate immune system,triggered by cyclic dinucleotides to induce antimicrobial immune responses.Beyond its role in host defense,STING activation also significantly contributes to the regulation of anti-tumor immune re-sponses.Consequently,STING agonists are extensively utilized in research targeting pathogen infec-tion and tumor immunotherapy.However,natural STING agonists exhibit poor stability and limited cell membrane permeability,underscoring the importance of developing novel agonists and efficient delivery systems.This review summarizes recent advances in the design of STING agonists and their delivery strategies,aiming to provide new perspectives for the clinical application of STING pathway modulation in immunotherapy.关键词
cGAS-STING通路/STING激动剂/递送策略/纳米材料/癌症免疫治疗Key words
cGAS-STING pathway/STING agonists/delivery strategies/nanomaterials/cancer immunotherapy分类
生物学引用本文复制引用
闫慧杰,黄琳,吴军军..新型STING激动剂及递送策略的研究进展[J].福建师范大学学报（自然科学版）,2025,41(6):87-94,8.基金项目
国家自然科学基金项目(22307019) （22307019）
福建省自然科学基金面上项目(2023J01506) （2023J01506）
翔安创新实验室/传染病疫苗研发全国重点实验室科技项目(2023XAKJ0101011) （2023XAKJ0101011）
