分析测试学报2025，Vol.44Issue(11)：2229-2235,7.DOI:10.12452/j.fxcsxb.25010913
纳米金及导电金属有机框架修饰MXene复合材料构建甲胎蛋白电化学免疫传感器
Electrochemical Immunosensor Based on Au Nanoparticles and Conductive Metal-Organic Framework Modified MXene Composites for Detection of Alpha-Fetoprotein
摘要
Abstract
In this study,the conductive metal-organic framework(Cu3(HITP)2)nanosheet struc-tures were successfully growth on titanium carbide(MXene)via wet etching and in situ growth meth-ods.Au nanoparticles(Au NPs)were modified on the surface of Cu3(HITP)2-MXene nanocomposites using a chemical reduction technique.The morphology and elemental composition of the synthesized samples were systematically characterized through scanning electron microscopy(SEM)and X-ray photoelectron spectroscopy(XPS).The electrochemical performances of the as-developed Au NPs@Cu3(HITP)2-MXene immunosensor were investigated by cyclic voltammetry(CV),electro-chemical impedance spectroscopy(EIS)and differential pulse voltammetry(DPV).The obtained re-sults demonstrated that the electrochemical immunosensor displays a linear range from 100 fg/mL to 10 μg/mL with a low detection limit of 35 fg/mL,as well as excellent selectivity and stability toward alpha-fetoprotein(AFP).As results,the as-proposed electrochemical immunosensor based on Au NPs@Cu3(HITP)2-MXene nanocomposites exhibits highly performances toward AFP detection,which is potential for the application for the analysis of human serum sample.关键词
电化学免疫传感器/导电金属有机框架/碳化钛/金纳米颗粒/甲胎蛋白Key words
electrochemical immunosensor/conductive metal organic framework/titanium car-bide/Au nanoparticles/alpha-fetoprotein分类
化学引用本文复制引用
戴灿源,白锦源,张航滔,李京谦,王文达,胡杰..纳米金及导电金属有机框架修饰MXene复合材料构建甲胎蛋白电化学免疫传感器[J].分析测试学报,2025,44(11):2229-2235,7.基金项目
中央引导地方项目(YDZJSX20231A011) （YDZJSX20231A011）
山西省自然科学基金项目(202203021221073) （202203021221073）
山西省大学生创新训练计划项目(20250166) （20250166）
