高等学校化学学报2025，Vol.46Issue(11)：11-20,10.DOI:10.7503/cjcu20250163
碘化亚铜簇基闪烁体的制备及X射线激发活性氧产生性能
Fabrication of Copper(I)Iodide Cluster-based Scintillator for Highly Efficient X-ray-excited Reactive Oxygen Species Generation
摘要
Abstract
Cuprous iodide cluster-based complexes exhibit significant potential in scintillator materials due to their structural diversity,strong X-ray absorption capacity and tunable excited-state properties.However,crystalline state is typically required to achieve efficient luminescence,and mechanical grinding often induces mechanochromic effects,which severely limit their biomedical applications.In this study,a series of Cu4I4Py4 complex-based scintilla-tors was prepared via a facile solution processing method.The effects of crystal structure,co-crystallized solvent molecule,and polymer matrix on their luminescent performance were systematically investigated.In addition,polystyrene(PS)was employed as an encapsulation matrix to modulate the emission wavelength of the scintillators,enabling spectral overlap with the photosensitizer(methylene blue,MB)for enhanced energy transfer efficiency.The encapsulation simultaneously improved biocompatibility and bioenvironmental stability of the scintillation complex,yielding a type of photosensitizer nanoparticles(Cu4I4Py4-PS-MB)with high X-ray irradiation resistance.The results of N,N-dimethyl-4-nitrosoacniline(RNO)bleaching(RNO-imidazole)experiments confirmed that this nanocomposite system exhibits exceptionally high singlet oxygen(1O2)yields under both UV light and X-ray irradia-tion,demonstrating its potential for constructing efficient and stable X-ray photodynamic therapy(X-PDT)nanoplat-form.This work provides a novel solution for deep-tumor photodynamic therapy by overcoming the limitations of tradi-tional scintillator materials.关键词
碘化亚铜簇基配合物/X射线闪烁体/深层肿瘤治疗/光动力学治疗Key words
Cuprous iodide cluster complex/X-ray scintillator/Deep tumor therapy/Photodynamic therapy分类
化学化工引用本文复制引用
肖康,薛程文,沈嘉成,刘湘梅..碘化亚铜簇基闪烁体的制备及X射线激发活性氧产生性能[J].高等学校化学学报,2025,46(11):11-20,10.基金项目
南京邮电大学校级自然科学基金(批准号:NY223120)和江苏省大型科研仪器开放共享自主研究课题(批准号:TC2024A020)资助. Supported by the Natural Science Foundation of Nanjing University of Posts and Telecommunications,China(No.NY223120)and the Jiangsu Independent Research Project on Opening and Sharing of Large-Scale Scientific Research Instruments,China(No.TC2024A020). （批准号:NY223120）
