高等学校化学学报2025，Vol.46Issue(11)：60-68,9.DOI:10.7503/cjcu20250176
超声辅助自组装构建多功能铁-原卟啉纳米粒及多模态肿瘤治疗
Ultrasonically Assisted Self-assembly of Multifunctional Iron-protoporphyrin Nanoparticles and Multimodal Tumor Therapy
摘要
Abstract
Multimodal synergistic therapeutic nanomaterials exhibit significant research value for precision tumor therapy.However,the traditional preparation process is complex and the therapeutic efficacy of synergistic therapy remains suboptimal.In this work,an ultrasonically assisted self-assembly strategy is developed to synthesize iron-protoporphyrin IX(PpIX)coordination particle(Fe-PpIX).This approach achieves a three-in-one multimodal tumor therapy through photodynamic/sonodynamic/chemodynamic therapy.The prepared nanoparticles were characterized by the transmission electron microscope(TEM),X-ray photoelectron spectroscopy(XPS)and Fourier transform infrared spectroscopy(FTIR),which indicated that Fe was coordinated with PpIX by carboxyl groups.The quantita-tive evaluation of fluorescence spectroscopy demonstrated the efficient ROS generation of Fe-PpIX under photody namic and sonodynamic conditions.The o-phenylenediamine/methylene blue dual probes further revealed that Fe-PpIX can catalyze the H2O2,which produces hydroxyl radicals by Fenton-like reaction.The MTT assays of L929 and 4T1 cells indicate that Fe-PpIX possesses good biocompatibility.After light/sound synergistic therapy,the survival rate of 4T1 tumor cells decreased significantly,and the survival rate decreased to the lowest(15.0%).This was further confirmed by live/dead cell staining experiments.The developed nanoparticles exhibit a valuable potential for achieving highly efficient therapy,providing a promising strategy for the rational design of multimodal therapeutic nanomaterials.关键词
自组装/多模态协同治疗/原卟啉PpIX/光动力/声动力Key words
Self-assembly/Multimodal synergistic therapy/Protoporphyrin IX/Photodynamic/Sonodynamic分类
化学引用本文复制引用
李勇,李燕,杨景儿,王柏萍,尹君雅,耿鹏,杨扬,黄文权..超声辅助自组装构建多功能铁-原卟啉纳米粒及多模态肿瘤治疗[J].高等学校化学学报,2025,46(11):60-68,9.基金项目
广西药物分子发现与成药性优化重点实验室开放课题(批准号:GKLDDO-2024-05)、湖北省自然科学基金(批准号:2024AFB059)和三峡大学高层次人才科研启动及平台建设经费(拔尖人才)(批准号:8220309)资助. Supported by the Project Program of Guangxi Key Laboratory of Drug Discovery and Optimization,China(No.GKLDDO-2024-05),the Natural Science Foundation of Hubei Province,China(No.2024AFB059)and the Scientific Research Start-up and Platform Construction of China Three Gorges University High-level Talents(top-notch talents),China(No.8220309). （批准号:GKLDDO-2024-05）
