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Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice

Fangxi Xu Yuqi Guo Scott C.Thomas Anish Saxena Samantha Hwang Mridula Vardhan Xin Li

国际口腔科学杂志（英文版）2025，Vol.17Issue(5)：643-653,11.

国际口腔科学杂志（英文版）2025，Vol.17Issue(5)：643-653,11.DOI:10.1038/s41368-025-00376-6

Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice

Fangxi Xu ¹Yuqi Guo ²Scott C.Thomas ¹Anish Saxena ¹Samantha Hwang ¹Mridula Vardhan ¹Xin Li³

作者信息

1. Department of Molecular Pathobiology,New York University College of Dentistry,New York,NY,USA
2. Department of Molecular Pathobiology,New York University College of Dentistry,New York,NY,USA||Plastic Surgery,Maxillofacial and Oral Health Department,University of Virginia School of Medicine,Charlottesville,VA,USA
3. Department of Molecular Pathobiology,New York University College of Dentistry,New York,NY,USA||Plastic Surgery,Maxillofacial and Oral Health Department,University of Virginia School of Medicine,Charlottesville,VA,USA||The UVA Comprehensive Cancer Center,School of Medicine,Charlottesville,VA,USA||Department of Neuroscience,University of Virginia School of Medicine,Charlottesville,VA,USA
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Fangxi Xu,Yuqi Guo,Scott C.Thomas,Anish Saxena,Samantha Hwang,Mridula Vardhan,Xin Li..Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice[J].国际口腔科学杂志（英文版）,2025,17(5):643-653,11.

基金项目

This work was supported by NIH grants DE027074,DE028212,and AG055787 to Xin Li.Additionally,the study benefited from the NYUCD microCT Core and NYU IT High Performance Computing resources,services,and staff expertise. （）

国际口腔科学杂志（英文版）

ISSN：1674-2818

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