赣南医科大学学报2025，Vol.45Issue(9)：825-829,5.DOI:10.3969/j.issn.1001-5779.2025.09.001
芒果苷脂质体的制备与表征
Preparation and characterization of mango glycoside liposome nanoparticles
摘要
Abstract
Objective:To screen the preparation method and the optimal prescription of mangiferin liposomes.Methods:The average particle size,polydispersity index(PDI),and Zeta potential were used as evaluation indicators.The L9(34)orthogonal experiment was conducted to determine the optimal prescription and preparation method of mangiferin liposomes.The prepared mangiferin liposomes with the optimal prescription and preparation method were characterized,and the entrapment efficiency was determined by high performance liquid chromatography.Results:The optimal prescription was DOTAP∶cholesterol∶sunflower phospholipid∶mangiferin=2∶6∶1.5∶1(molar ratio),and the film hydration method was the best for the preparation of the liposomes.The average particle size of the product was(182.20±2.25)nm,the PDI was(0.148±0.001),and the Zeta potential was(45.70±0.56)mV.The morphology of the mangiferin liposomes was nearly spherical under scanning electron microscopy.The entrapment efficiency was 93.85%.Conclusion:The prepared mangiferin liposomes had a small average particle size,a uniform and stable liposome system,and a nearly spherical morphology,which met the standards of liposomes.关键词
芒果苷/脂质体/制备Key words
Mangiferin/Liposomes/Preparation分类
医药卫生引用本文复制引用
叶民珠,胡雨平,戴伟,张玉清,申金玉,黄浩..芒果苷脂质体的制备与表征[J].赣南医科大学学报,2025,45(9):825-829,5.基金项目
国家自然科学基金国际合作项目(82111530101) （82111530101）
江西省杰出青年基金项目(20212ACB216002) （20212ACB216002）
江西省教育厅科学技术研究项目(GJJ2201439) （GJJ2201439）
