摘要
Abstract
Objective:To evaluate the effect of gastrodin injection and betahistine hydrochloride injection in patients with vertebrobasilar artery insufficiency vertigo(VBIV)and its effect on cerebral blood perfusion and serum interleukin-enhanced binding factor-1(ILF-1)and endothelin(ET).Methods:A total of 96 VBIV patients admitted to our hospital from January 2023 to September 2024 were prospectively selected.They were divided into betahistine hydrochloride group(48 cases)and combination group(48 cases)according to the randomized control table.The betahistine hydrochloride group was given betahistine hydrochloride injection after surgery,and the combination group was given gastrodin injection and betahistine hydrochloride injection.The treatment efficacy,vertigo frequency and duration of vertigo attacks and dizziness handicap inventory(DHI)score,vertebrobasilar blood flow velocity(mean blood flow velocity of vertebral artery,mean blood flow velocity of basilar artery),cerebral blood volume(CBV),cerebral blood flow(CBF)and mean transit time(MTT)and serum ILF-1 and ET were compared.Results:Before treatment,there was no significant difference between the two groups(P＞0.05).After treatment,the total response rate of the combination group(95.83%)was higher than that of the betahistine hydrochloride group(72.92%);mean blood flow velocity of vertebral artery,mean blood flow velocity of basilar artery,CBV and CBF in the combination group were higher than those in betahistine hydrochloride group,and frequency and duration of vertigo episodes,and DHI score,MTT,serum ILF-1 and ET in the combined drug group were lower than those in betahistine hydrochloride group,with significant differences(P＜0.05).Conclusion:In VBIV patients,gastrodin injection combined with betahistine hydrochloride injection can significantly improve the blood circulation of vertebrobasilar artery and cerebral blood perfusion,restore blood supply to the brain,reduce the level of serum ILF-1 and ET,and inhibit inflammation,alleviate vertigo symptoms.关键词
椎基底动脉供血不足性眩晕/天麻苷/盐酸倍他司汀/脑血流灌注量/白细胞介素增强结合因子-1/内皮素Key words
Vertebrobasilar artery insufficiency vertigo/Gastrodin/Betahistine hydrochloride/Cerebral blood perfusion/Interleukin-enhanced binding factor-1/Endothelin分类
医药卫生
