国际口腔医学杂志2025，Vol.52Issue(6)：791-797,7.DOI:10.7518/gjkq.2025104
牙龈EB病毒阳性弥漫性大B细胞淋巴瘤1例
A case report of gingival Epstein-Barr virus-positive diffuse large B-cell lymphoma
摘要
Abstract
Epstein-Barr virus-positive diffuse large B-cell lymphoma(EBV+DLBCL)is a rare and aggressive type of B-cell lymphoma that typically occurs in elderly patients and is associated with a poor prognosis.It commonly affects ex-tranodal sites such as the gastrointestinal tract,skin,and bone marrow.EBV+DLBCL presenting with initial symptoms in the gingiva is extremely rare.Its similarity to EBV-positive mucocutaneous ulcer(EBVMCU)in terms of pathology and immunophenotype makes definitive diagnosis challenging.In this work,we report a case initially diagnosed as EBVMCU but later confirmed as EBV+DLBCL through lymphoma gene rearrangement technology.The clinical manifestations and pathological histological features of the patient are pre-sented to enhance understanding of the disease and con-tribute to early diagnosis and treatment of such malig-nant diseases.关键词
EB病毒/弥漫性大B细胞淋巴瘤/口腔溃疡/基因重排/临床病理Key words
EB virus/diffuse large B-cell lympho-ma/oral ulcer/gene rearrangement/clinical patholo-gy分类
临床医学引用本文复制引用
黄润语,赵晓娴,张春叶,张颖,周永梅,吴岚..牙龈EB病毒阳性弥漫性大B细胞淋巴瘤1例[J].国际口腔医学杂志,2025,52(6):791-797,7.基金项目
Project of Science and Technology Commission of Shanghai(21S21902000) （21S21902000）
Project of Shanghai Munici-pal Health Commission[ZY(2021-2023)-0207-01-04,2022CX009] （2021-2023）
Cross Project Cooperation Fund of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine(JYJC202111) 上海市科学技术委员会基金(21S21902000) （JYJC202111）
上海市卫生健康委员会项目[ZY(2021-2023)-0207-01-04,2022CX009] （2021-2023）
上海交通大学医学院附属第九人民医院交叉基金(JYJC202111) （JYJC202111）
