国际口腔医学杂志2025，Vol.52Issue(6)：806-815,10.DOI:10.7518/gjkq.2025097
口腔及肠道微生物与儿童全身系统性疾病的相关性研究进展
Research progress on the relationship among oral microbiota,gut microbiota,and systemic diseases in children
摘要
Abstract
The oral cavity is a gateway to the gastrointestinal tract.The relative abundance of common oral bacteria in the intestine of individuals with systemic diseases increases.The oral microbiota interact with the intestinal microbiota,which induces intestinal dysbiosis and intestinal mucosa damage.Compared with the oral and intestinal microbiota of adults,those of children are more sensitive to external stimuli,and they change dynamically with growth and develop-ment.Childhood may be the critical time for microbiota interventions to prevent diseases.This review discusses the estab-lishment and development of oral and intestinal microbiota.The relationship between oral microbiota and intestinal micro-biota in children with systemic diseases is also determined.This review offers new avenues for the prevention,diagnosis,and treatment of diseases.关键词
口腔微生物/肠道微生物/儿童/系统性疾病Key words
oral microbiomes/gastrointestinal mi-crobiomes/children/system diseases分类
临床医学引用本文复制引用
冯涵果,饶南荃,曾馨仪,余思源,刘娟..口腔及肠道微生物与儿童全身系统性疾病的相关性研究进展[J].国际口腔医学杂志,2025,52(6):806-815,10.基金项目
National Key Clinical Specialty Development Project of Pediatric Dentistry Division(20230610) （20230610）
Scienti-fic Research Project of Education Department of Yunnan Province(2025J0168) （2025J0168）
Clinical Scientific Research Project of National Key Clinical Specialty Development Project of Pediatric Dentistry Division(EYQ2024002) 国家临床重点专科儿童口腔科建设项目(20230610) （EYQ2024002）
云南省教育厅科学研究基金(2025J0168) （2025J0168）
国家临床重点专科儿童口腔科建设项目临床科研青年基金项目(EYQ2024002) （EYQ2024002）
