保健医学研究与实践2025，Vol.22Issue(7)：144-149,6.DOI:10.11986/j.issn.1673-873X.2025.07.23
CAR-T疗法治疗自身免疫性疾病的优势与临床应用
Advantages and clinical applications of CAR-T therapy for autoimmune diseases
摘要
Abstract
Chimeric antigen receptor T-cell(CAR-T)therapy is a genetic engineering-mediated immune cell therapy that selec-tively targets and kills diseased cells by reprogramming a patient's own T cells.In recent years,it has achieved remarkable success in oncology,and its application has gradually expanded into non-tumor fields such as autoimmune diseases,demonstra-ting substantial development potential.This paper reviews the advantages of CAR-T therapy for treating autoimmune diseases and summarizes its clinical applications and efficacy in conditions such as systemic lupus erythematosus.Future development of this therapy should focus on continuous evaluation of efficacy and risk,exploration of additional therapeutic targets,and reduc-tion of treatment costs to benefit more patients.关键词
嵌合抗原受体T细胞疗法/自身免疫性疾病/临床应用Key words
Chimeric antigen receptor T-cell therapy/Autoimmune diseases/Clinical applications分类
临床医学引用本文复制引用
游学楷,江剑平..CAR-T疗法治疗自身免疫性疾病的优势与临床应用[J].保健医学研究与实践,2025,22(7):144-149,6.基金项目
国家自然科学基金项目(31371124) （31371124）
教育部产学合作协同育人项目(202101099013) （202101099013）
福建师范大学课程思政示范课程项目(KZ2023020) （KZ2023020）
福建师范大学本科教学改革研究项目(I202201068) （I202201068）
福建师范大学首批虚拟教研室项目. （）
