高校化学工程学报2025，Vol.39Issue(5)：788-798,11.DOI:10.3969/j.issn.1003-9015.2025.00.024
连续流动生物催化中NAD(P)H再生研究进展
Research progress in NAD(P)H regeneration in continuous flow biocatalysis
摘要
Abstract
Continuous flow chemistry,a transformative technology enabling chemical reactions in continuous flow systems,has gained significant importance in pharmaceuticals,chemical engineering,energy,and materials sci-ence.The integration of enzymatic catalysis,particularly valued for its exceptional enantioselectivity,has demon-strated remarkable advantages for pharmaceutical synthesis in flow systems.However,achieving efficient and cost-effective regeneration of oxidoreductase cofactors NAD(P)+remains a critical scientific challenge.This review com-prehensively summarizes recent advances in cofactor recycling strategies within continuous flow biocatalytic systems,critically examines key limitations in current cofactor regeneration approaches,and proposes future research direc-tions to accelerate the industrial applications of flow-based biocatalysis.关键词
流动化学/辅因子循环/微反应器/生物催化/电化学/光化学Key words
flow chemistry/co-factors regeneration/microreactor/biocatalysis/electrochemistry/photo-chemistry分类
生物工程引用本文复制引用
何长安,段金电,王志祥,张全,杨照,胡玉静..连续流动生物催化中NAD(P)H再生研究进展[J].高校化学工程学报,2025,39(5):788-798,11.基金项目
国家自然科学基金(22308158) （22308158）
江苏省高等学校基础科学自然科学研究面上项目(23KJB530008) （23KJB530008）
中国石化重大科技项目(2350639042). （2350639042）
