黑龙江动物繁殖2025，Vol.33Issue(5)：26-30,5.DOI:10.19848/j.cnki.ISSN1005-2739.2025.10.0004
表观遗传修饰影响家畜精子发生过程研究
Research advances in epigenetic modifications influencing the spermatogenesis process in livestock
摘要
Abstract
Spermatogenesis determines the reproductive capacity of male livestock.This review summarizes the regulatory roles of epigenetic modifications in the spermatogenesis process of livestock,with a focused analysis on the research progress regarding the involvement of three major types of modifications—DNA methylation,histone modifications,and non-coding RNAs—in key stages such as spermatogonial stem cell renewal,meiosis,and sperm maturation.It introduces how epigenetic factors play crucial roles in spermatogenesis and the maintenance of male fertility by regulating gene expression,chromatin remodeling and transposon silencing.Furthermore,the review prospects the application potential of multi-omics technologies and epigenetic editing techniques in future breeding programs,aiming to provide a theoretical basis and novel insights for in-depth research into the molecular regulatory mechanisms underlying male livestock reproductive efficiency.关键词
精子发生/表观遗传修饰/DNA甲基化/组蛋白修饰/非编码RNAKey words
spermatogenesis/epigenetic modifications/DNA methylation/histone modifications/non-coding RNA分类
农业科技引用本文复制引用
刘春江,庞静,申依菲,魏宗友,杨花..表观遗传修饰影响家畜精子发生过程研究[J].黑龙江动物繁殖,2025,33(5):26-30,5.基金项目
南京农业大学基本科研业务费专项(YDZX2025004) （YDZX2025004）
江苏省卓越博士后计划项目(2023ZB334) （2023ZB334）
