红外与毫米波学报2025，Vol.44Issue(5)：663-670,8.DOI:10.11972/j.issn.1001-9014.2025.05.004
精准对齐的共轴可见光-近红外二区双通道手术导航系统及其在临床人血供评估中的应用
Alignment-optimised coaxial visible-NIR-Ⅱ dual-channel surgical navigation system and its clinical application in blood-supply assessment
摘要
Abstract
Fluorescence imaging in the second near-infrared window(NIR-Ⅱ,900-1880 nm)offers high signal-to-background ratio(SBR),enhanced definition,and superior tissue penetration,making it ideal for real-time surgical navigation.However,with single-channel imaging,surgeons must frequently switch between the surgi-cal field and the NIR-Ⅱ images on the monitor.To address this,a coaxial dual-channel imaging system that com-bines visible light and 1 100 nm longpass(1100LP)fluorescence was developed.The system features a custom-ized coaxial dual-channel lens with optimized distortion,achieving precise alignment with an error of less than±0.15 mm.Additionally,the shared focusing mechanism simplifies operation.Using FDA-approved indocya-nine green(ICG),the system was successfully applied in dual-channel guided rat lymph node excision,and blood supply assessment of reconstructed human flap.This approach enhances surgical precision,improves opera-tional efficiency,and provides a valuable reference for further clinical translation of NIR-Ⅱ fluorescence imaging.关键词
近红外二区/双通道/荧光成像/手术导航/共轴光路Key words
NIR-Ⅱ/dual-channel/fluorescence imaging/surgical navigation/coaxial分类
物理学引用本文复制引用
张浴煌,刘孝龙,孙思颖,樊潇霄,林辉,钱骏..精准对齐的共轴可见光-近红外二区双通道手术导航系统及其在临床人血供评估中的应用[J].红外与毫米波学报,2025,44(5):663-670,8.基金项目
Supported by the National Natural Science Foundation of China(U23A20487) （U23A20487）
the National Key R&D Program of China(2022YFB3206000) （2022YFB3206000）
Dr.Li Dak Sum&Yip Yio Chin Development Fund for Regenerative Medicine,Zhejiang University （）
the National Natural Science Foundation of China(61975172). （61975172）
