红外与毫米波学报2025，Vol.44Issue(5)：801-818,18.DOI:10.11972/j.issn.1001-9014.2025.05.018
近红外二区生物医学光学:从技术进展向临床转化的演进与展望
NIR-Ⅱ biomedical optics:evolution and prospects from technological advances towards clinical translation
摘要
Abstract
The second near-infrared window(NIR-Ⅱ,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back-ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-Ⅱ photodiagnosis and phototherapy research over the past decade,bibliometric analy-sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-Ⅱ-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur-rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re-search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-Ⅱ imaging clini-cal trials.This study delineates the NIR-Ⅱ research trajectory,highlighting China's leadership,intensifying glob-al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-Ⅱ probe devel-opment for NIR-Ⅱ imaging and clinical translation of photodynamic/immunotherapy combinational platforms.关键词
近红外二区/生物医学光学/临床转化/研究趋势Key words
second near-infrared window(NIR-Ⅱ)/biomedical optics/clinical translation/research trend分类
数理科学引用本文复制引用
李奕暄,钱骏,樊潇霄,林辉,夏启铭,陈国巧,张译尹,刘孝龙,Sofia Abdulkadir Adam,金盛曦,周凤彬,林登峰..近红外二区生物医学光学:从技术进展向临床转化的演进与展望[J].红外与毫米波学报,2025,44(5):801-818,18.基金项目
Supported by National Natural Science Foundation of China(81874059 and 82102105) （81874059 and 82102105）
the Natural Science Foundation of Zhejiang Province(LQ22H160017) （LQ22H160017）
the China Postdoctoral Science Foundation(2021M702825). （2021M702825）
