基础医学与临床2025，Vol.45Issue(11)：1438-1443,6.DOI:10.16352/j.issn.1001-6325.2025.11.1438
中国人群中久坐时间与全因死亡及心血管疾病的关联
Association of sitting time with all-cause mortality and cardiovascular disease in the Chinese population
摘要
Abstract
Objective To explore potential association between sedentary time and the risk of all-cause mortality and cardiovascular disease(CVD)in Chinese population using data from the Prospective Urban Rural Epidemiology(PURE-China)cohort study.Methods Baseline data were collected,from 2022 standardized questionnaires and physical examinations,with follow-up until August 31,2022.The primary endpoints were all-cause mortality and cardiovascular events(non-fatal myocardial infarction,stroke or heart failure).Multivariable Cox shared frailty model was used to analyze the association between sedentary time and the risks of all-cause mortality and CVD in the target population,and to compare differences across subgroups based on gender,age and geographic location.Results A total of 47 931 participants were recruited,and 43 367 were included in the final analysis.Over a me-dian follow-up of 11.9±3.0 years,2 277 participants experienced all-cause mortality,3 551 experienced cardiovas-cular events.The Cox model indicated that,compared to individuals with less than 4 h of sedentary time per day,those with 6-8 h had a 23％increased in risk of all-cause mortality(HR=1.23,95％CI:1.06-1.44)and an 18％increased risk of CVD(HR=1.18,95％CI:1.04-1.33).For individuals with more than 8 h of sedentary time,the risk increased by 50％for all-cause mortality(HR=1.50,95％CI:1.16-1.94)and 44％for CVD(HR=1.44,95％CI:1.16-1.79).These associations were more pronounced in men and individuals aged 50 years and older.Conclusions Sedentary behavior is associated with an increased risk of all-cause mortality and cardiovascular disease in Chinese population,especially in the population with sedentary time of 6 hrs or more per day.Reducing sedentary time and increasing physical activity is an important strategy to mitigate the disease burden of cardiovascular disease and premature death.关键词
久坐/心血管疾病/队列研究/全因死亡/风险比Key words
sedentary behavior/cardiovascular disease/cohort study/all-cause mortality/hazard ratio分类
医药卫生引用本文复制引用
兰磊,郎欣月,陈飞龙,王慧,何国敏,李卫,刘之光,代表前瞻性城乡流行病学研究中国地区协作者..中国人群中久坐时间与全因死亡及心血管疾病的关联[J].基础医学与临床,2025,45(11):1438-1443,6.基金项目
国家心血管疾病临床医学研究中心·深圳自主课题(NCRCSZ-2023-012) （NCRCSZ-2023-012）
