基础医学与临床2025，Vol.45Issue(11)：1496-1500,5.DOI:10.16352/j.issn.1001-6325.2025.11.1496
丁酰化修饰在恶性肿瘤中作用的研究进展
Research progress on the role of butyrylation modification in malignant tumors
摘要
Abstract
Butyrylation(Kbu),as an important post-translational modification(PTM)of proteins,precisely regu-lates various biological behaviors of tumor cells by modulating the structure and function of proteins.Abnormal bu-tyrylation promotes tumor cell proliferation and migration by regulating protein stability,enzyme activity,cell signa-ling pathways,chromatin structure and gene expression,and further participates in tumor occurrence and develop-ment.This review focuses on the role of butyrylation modification in the occurrence and development of various hu-man tumors,aiming to summarize the research progress of butyrylation modification in the field of tumors,and to provide new directions for tumor treatment through the intervention strategies of butyrylation modification.关键词
丁酰化/恶性肿瘤/翻译后修饰Key words
butyrylation/malignant tumor/post-translational modification分类
临床医学引用本文复制引用
石冬雪,王瑞涵,吕蓓蓓,林晓燕..丁酰化修饰在恶性肿瘤中作用的研究进展[J].基础医学与临床,2025,45(11):1496-1500,5.基金项目
国家自然科学基金(82103490,81972474) （82103490,81972474）
