基础医学与临床2025，Vol.45Issue(11)：1501-1505,5.DOI:10.16352/j.issn.1001-6325.2025.11.1501
Poly(C)-结合蛋白1在铁死亡中的研究进展
Progress on poly(C)-binding protein 1 in ferroptosis
摘要
Abstract
Poly(C)-binding protein 1(PCBP1)is a multifunctional RNA-binding protein involved in a series of processes such as gene transcription,selective modification,translation and regulation of iron metabolism.This pa-per explores the pathway through which PCBP1 inhibits ferroptosis during the research on PCBP1-related diseases,such as bladder cancer and head and neck cancer.PCBP1 can reduce the intracellular ferrous iron content to inhib-it ferroptosis through the mechanisms like inhibiting ferritinophagy,promoting the transfer of iron ions to ferritin or iron-dependent enzymes,stabilizing the labile iron pool within cells and facilitating the formation of[2Fe-2S]clus-ters.PCBP1 can also reduce the generation of lipid peroxides and enhance the resistance to oxidative stress thus to reduce the level of intracellular reactive oxygen thereby inhibiting ferroptosis.关键词
poly(C)-结合蛋白1(PCBP1)/铁死亡/铁蛋白/脂质过氧化Key words
poly(C)-binding protein 1(PCBP1)/ferroptosis/ferritin/lipid peroxidation分类
医药卫生引用本文复制引用
刘甜娜,李阳,邓雨笛,吴富菊..Poly(C)-结合蛋白1在铁死亡中的研究进展[J].基础医学与临床,2025,45(11):1501-1505,5.基金项目
吉林省科技发展计划(20230508077RC) （20230508077RC）
