激光生物学报2025，Vol.34Issue(5)：385-392,400,9.DOI:10.3969/j.issn.1007-7146.2025.05.001
工业级玻璃微反应器激光三维打印技术及其在流动化学中的应用
Industrial-scale Micro-reactors in Glass Fabricated by Laser 3D Printing for Flow Chemistry Applications
摘要
Abstract
Over the past few decades,ultrafast laser internal modification technology has emerged as a widely adopted method for the three-dimensional(3D)micromachining of transparent materials,enabling the fabrication of complex structures and devices with exceptional geometric freedom.However,the direct application of laser 3D printing technology for the production of industrial-scale complex devices composed of hard and brittle materials such as glass and ceramics still poses significant challenges.This paper first elucidates the mechanisms by which extreme spatiotemporal control of ultrafast laser-material interactions can be achieved deep inside of transparent materials.The development of a high-resolution,high-throughput ultrafast laser 3D printing technology tailored for the manufacture of industrial-scale glass microreactors is also reviewed.The resulting glass microreactors exhibit both flexible 3D microchannel architectures and large liquid holding volumes.Their successful implementation in the high-throughput,high-performance continuous flow synthesis of advanced pharmaceuticals and chemicals is poised to catalyze a new technological revolution in the field of flow chemistry.关键词
激光三维打印/微反应器/微流控/流动化学/飞秒激光微加工Key words
laser three-dimensional printing/microreactor/microfluidics/flow chemistry/femtosecond laser micromachining分类
物理学引用本文复制引用
汪旻,吴淼,程亚..工业级玻璃微反应器激光三维打印技术及其在流动化学中的应用[J].激光生物学报,2025,34(5):385-392,400,9.基金项目
国家自然科学基金项目(12192251,12334014,12474378,12174107) （12192251,12334014,12474378,12174107）
上海市市级科技重大专项(2019SHZDZX01). （2019SHZDZX01）
