激光生物学报2025，Vol.34Issue(5)：393-400,8.DOI:10.3969/j.issn.1007-7146.2025.05.002
褐藻胶制备技术与应用研究进展
Research Advances in Alginate Preparation Technology and Applications
摘要
Abstract
Alginate,a natural anionic polysaccharide derived from brown algae or microorganisms(e.g.,Azotobacter,Pseudomonas),exhibits unique gelling properties and biocompatibility with broad applications in food,pharmaceutical,and material industries.However,limitations including high molecular weight,poor water solubility,and low bioavailability restrict its utilization in high-value biomedicine.Alginate oligosaccharides(AOS)—degradation products of alginate—demonstrate superior potential due to their low molecular weight and enhanced bioactivities,e.g.,antioxidant,immunomodulatory,glucose/lipid regulatory effects.Notably,sodium oligomannate(GV-971)has been developed as a novel therapeutic agent targeting the gut-brain axis for Alzheimer's disease treatment.This review systematically examines innovative extraction processes for marine algal alginate,alginate lyase development and oligosaccharide preparation and microbial fermentation production of alginate.We anticipate a historic paradigm shift in the alginate industry—from marine resource-dependence to microbial bio-manufacturing.Future research should focus on converging technologies,such as dual-production microbial cell factories,AI-guided fermentation,overcoming industrialization bottlenecks involving cost reduction,standardization,safety risk management;and expanding high-value applications involving precision medicine;sustainable materials;to advance lab-scale innovations toward scalable industrial implementation.关键词
褐藻胶/褐藻胶裂解酶/褐藻胶寡糖/微生物褐藻胶/提取工艺Key words
alginate/alginate lyase/alginate oligosaccharides/microbial alginate/extraction process分类
轻工业引用本文复制引用
周小棉,何晨淼,韦春爱,刘新章,黄祖坤,尹业师..褐藻胶制备技术与应用研究进展[J].激光生物学报,2025,34(5):393-400,8.基金项目
广西壮族自治区大学生创新创业训练计划(S202410593417) （S202410593417）
国家自然科学基金区域创新发展联合基金重点支持项目(U21A20411). （U21A20411）
