解剖学杂志2025，Vol.48Issue(5)：373-376,封2,5.DOI:10.3969/j.issn.1001-1633.2025.05.002
小鼠颞叶联合皮质的神经环路解析:与初级听觉皮质的差异
Neural circuitry analysis of the temporal association cortex in mice:Differences from the primary auditory cortex
史可 1何晨召 1陈亮1
作者信息
- 1. 复旦大学基础医学院人体解剖与组织胚胎学系,上海 200032
- 折叠
摘要
Abstract
Objective:To systematically delineate the afferent and efferent connectivity patterns of temporal association cortex(TeA),with particular focus on elucidating its divergent upstream inputs relative to primary auditory cortex(Au1).Methods:Using adult C57BL/6J wild-type mice,we performed bidirectional viral tracing through stereotaxic injections.For retrograde tracing,AAV2/retro-hSyn-mCherry was injected into either TeA or Au1 to label and quantify upstream input neurons.For anterograde tracing,HSV1-H129 was injected specifically into TeA to map and quantify its downstream projection targets.Results:Both Au1 and TeA received extensive upstream inputs,including ipsilateral and contralateral auditory cortices,thalamus and other cortical regions.Compared with Au1,TeA received more inputs from the limbic system and entorhinal cortex.Downstream projections showed that TeA targeted auditory cortex,auditory thalamus,amygdala,pontine nuclei and other brain regions.Conclusion:In contrast to Au1,TeA,as a multisensory integration hub,receives more inputs from the limbic system and cerebral cortex,and widely projects to brain regions related to emotion,movement and sensory regulation,suggesting its potential key role in sensory-motor integration networks.关键词
颞叶联合皮质/初级听觉皮质/病毒示踪/神经环路/小鼠Key words
temporal association cortex/primary auditory cortex/viral tracing/neural circuit/mouse分类
基础医学引用本文复制引用
史可,何晨召,陈亮..小鼠颞叶联合皮质的神经环路解析:与初级听觉皮质的差异[J].解剖学杂志,2025,48(5):373-376,封2,5.
