解剖学杂志2025，Vol.48Issue(5)：388-392,5.DOI:10.3969/j.issn.1001-1633.2025.05.005
红花注射液对糖尿病雄性大鼠睾丸氧化应激损伤的作用及机制
Effect and mechanism of safflower injection on testicular oxidative stress injury in male diabetic rats
摘要
Abstract
Objective:To investigate the effect and mechanism of safflower injection in alleviating oxidative stress-induced testicular damage in diabetic male rats.Methods:Male SD rats were randomly divided into three groups:a normal group,a model group,and a treatment group.The general condition and testicular mass of the rats were compared among the groups,plus the levels of superoxide dismutase(SOD)and malondialdehyde(MDA)in testicular tissue.Histological structure,cell morphology,and the rate of proliferating cell nuclear antigen(PCNA)-positive cells in testicular tissue were also evaluated.Results:Compared with the normal group,the model group exhibited poorer mental state,dull and yellowish fur,increased food and water intake,more urination and defecation,significantly reduced testicular mass,and markedly decreased SOD levels and increased MDA levels in the testicular tissue.Through the observation under a light microscope,there was decreased and disordered arrangement of spermatogenic cells in the testes along with a lower rate of PCNA-positive cells.Compared with the model group,the treatment group showed improved responsiveness,less pronounced dull and yellowish fur,reduced food and water intake,and less urination,significantly increased testicular mass,elevated SOD levels,and significantly decreased MDA levels in testicular tissue.Morphological lesions in testicular tissue were alleviated,and the rate of PCNA-positive cells was increased.Conclusion:Safflower injection can improve the testicular damage in male diabetic rats,and its mechanism may be related to the regulation of MDA and SOD in the oxidative stress system.关键词
糖尿病/氧化应激/红花注射液/睾丸损伤/大鼠Key words
diabetes/oxidative stress/safflower injection/testicular injury/rat分类
基础医学引用本文复制引用
徐国超,万千帆,刘银霞,曹洋,杨丹,许键炜..红花注射液对糖尿病雄性大鼠睾丸氧化应激损伤的作用及机制[J].解剖学杂志,2025,48(5):388-392,5.基金项目
国家自然科学基金(82160126) （82160126）
贵州省科学技术厅黔科合[LH字(2014)7087] （2014）
贵州医科大学2024年大学生创新创业训练计划项目(2024-73) （2024-73）
