解剖学杂志2025，Vol.48Issue(5)：399-404,6.DOI:10.3969/j.issn.1001-1633.2025.05.007
UHRF1、THBS2、BTG2在卵巢癌组织中的表达及其与病理参数和预后的关系
Expression of UHRF1,THBS2,and BTG2 in ovarian cancer tissue and their correlation with pathological parameters and prognosis
摘要
Abstract
Objective:To investigate the expression of ubiquitin-like with PHD and ring finger domain 1(UHRF1),thrombospondin 2(THBS2),and B-cell translocation gene 2(BTG2)in ovarian cancer tissues,and their correlation with pathological parameters and prognosis.Methods:Cancer tissues and adjacent normal tissues(＞5 cm from the tumor)were collected from 113 patients with ovarian cancer treated in our hospital between March 2017 and June 2019.Immunohistochemistry detection of positive expression of UHRF1,THBS2,and BTG2 in cancer tissues as well as paracancerous tissues.The relationship between the expression of UHRF1,THBS2,and BTG2 in cancer tissues and clinical pathological parameters in ovarian cancer patients was analyzed.Kaplan-Meier survival curves were plotted to assess the association between the expression of UHRF1,THBS2,and BTG2 in cancer tissues of ovarian cancer patients and prognosis survival rate.Clinicopathological parameters were compared between patients with favorable and poor prognosis.Cox regression was adopted to analyze the influencing factors of poor prognosis in ovarian cancer patients.Results:The positive expression rates of UHRF1 and THBS2 in ovarian cancer cancer tissues were significantly higher than those in paracancerous tissues,while the positive expression rate of BTG2 was prominently lower than that in paracancerous tissues.The expression of UHRF1,THBS2,and BTG2 in cancer tissues of ovarian cancer patients was associated with International Federationof Gynecologyand Obstetrics(FIGO)staging,differentiation degree,and lymph node metastasis.The 5-year survival rates of patients with the positive expression of UHRF1 and THBS2 were prominently lower than those of the negative expression groups,while the 5-year survival rate of the BTG2 positive expression group was significantly higher than those of the negative expression group.There were statistically obvious differences in FIGO staging,pathological type,differentiation degree,lymph node metastasis,expression of UHRF1,THBS2,and BTG2 between the poor and the good prognosis groups.Cox regression analysis showed that lymph node metastasis,UHRF1,THBS2,and BTG2 were independent factors affecting poor prognosis in ovarian cancer patients.Conclusion:The positive expression rates of UHRF1 and THBS2 in cancer tissues of ovarian cancer patients are prominently increased,while the positive expression rate of BTG2 is prominently decreased.These three factors are closely related to pathological parameters such as FIGO staging,differentiation,lymph node metastasis,and 5-year survival rate,and they serve as factors affecting poor prognosis.关键词
泛素样含PHD和环指结构域蛋白1/血小板反应蛋白2/B细胞易位基因2/卵巢癌/病理参数/预后Key words
ubiquitin-like with PHD and ring finger domain 1/thrombospondin 2/B-cell translocation gene 2/ovarian cancer/pathological parameters/prognosis分类
基础医学引用本文复制引用
闫振宇,郭锰,杨然,苏博,张海燕..UHRF1、THBS2、BTG2在卵巢癌组织中的表达及其与病理参数和预后的关系[J].解剖学杂志,2025,48(5):399-404,6.基金项目
河南省医学科技攻关联合共建项目(LHGJ2019010435) （LHGJ2019010435）
