实用心电与临床诊疗2025，Vol.34Issue(5)：649-653,5.DOI:10.13308/j.issn.2097-5716.2025.05.005
肝肾阴虚型高血压及其昼夜节律与心脑血管疾病相关性临床研究
Clinical study on correlation between hypertension with liver-kidney yin deficiency and its circadian rhythm with cardio-cerebrovascular diseases
摘要
Abstract
Objective To investigate the relationship between 24-hour ambulatory blood pressure(ABP)changes in hypertension patients with liver-kidney yin deficiency and the risk of cardio-cerebrovascular diseases,as well as the association between blood pressure circadian rhythm and the development of these diseases.Methods Clinical data of 123 hypertension patients with liver-kidney yin deficiency who had undergone 24-hour ABP monitoring were retrospectively analyzed.Based on the presence of coronary heart disease or cerebral infarction,these patients were divided into a cardiovascular disease group(n=29),a cerebrovascular disease group(n=34),a cardio-cerebrovascular disease group(n=28),and a control group(without coronary heart disease or cerebral infarction,n=32).The 24-hour systolic blood pressure(SBP),diastolic blood pressure(DBP),daytime SBP and DBP and their load,as well as nocturnal SBP and DBP and their load were summarized and compared among the groups.Results No significant nocturnal blood pressure decline was observed in hypertension patients with liver-kidney yin deficiency,and their circadian rhythm was disrupted;74％of the patients exhibited a non-dipper blood pressure pattern.However,no statistically significant difference in circadian rhythm was found among the groups(P＞0.05).Analysis of variance or Kruskal-Wallis tests revealed that except for nocturnal DBP,24-hour SBP and DBP,daytime SBP and DBP,nocturnal SBP,and corresponding blood pressure load all showed statistically significant differences between the disease groups and the control group(all P＜0.05).Intergroup comparisons indicated that the cardiovascular disease group had the highest blood pressure level and the greatest blood pressure load.Conclusion Hypertension patients with liver-kidney yin deficiency exhibit severe disruption of blood pressure circadian rhythm,predominantly presenting as a non-dipper pattern.Atherosclerosis may contribute to elevated blood pressure and load in the early stage of cardio-cerebrovascular diseases.However,with the aggravation of vascular sclerosis to the stage of combined cardio-cerebrovascular involvement,blood pressure level and load slightly decrease compared to the early phase.These findings highlight the importance of assessing cardio-cerebrovascular event risks alongside blood pressure management.关键词
肝肾阴虚型高血压/心脑血管疾病/血压昼夜节律/24 h动态血压Key words
hypertension with liver-kidney yin deficiency/cardio-cerebrovascular disease/blood pressure circadian rhythm/24-hour ambulatory blood pressure分类
临床医学引用本文复制引用
黄晶晶,任炜炜,杨萍,李永聪,白雪松,袁媛..肝肾阴虚型高血压及其昼夜节律与心脑血管疾病相关性临床研究[J].实用心电与临床诊疗,2025,34(5):649-653,5.基金项目
上海市闵行区卫生健康委科技项目(2023MW06) （2023MW06）
"龙华医院-闵行"中医专科(专病)联盟建设项目(2024LM03) （专病）
闵行区名中医工作室建设项目(mhmzy2024-03) （mhmzy2024-03）
徐州市科技局项目(KC23197) （KC23197）
徐州市卫生健康委项目(XWKYHT20210547) （XWKYHT20210547）
