实用心电与临床诊疗2025，Vol.34Issue(5)：654-658,664,6.DOI:10.13308/j.issn.2097-5716.2025.05.006
低流量氧气吸入对老年高血压合并阻塞性睡眠呼吸暂停综合征的治疗效果
Therapeutic effect of low-flow oxygen inhalation on elderly patients with hypertension complicated by obstructive sleep apnea syndrome
摘要
Abstract
Objective To analyze the therapeutic effect of low-flow oxygen inhalation in elderly patients with hypertension complicated by obstructive sleep apnea syndrome(OSAS).Methods A total of 175 elderly patients with hypertension and OSAS were selected as study subjects.All patients received conventional antihypertensive medication as recommended by guidelines.Those receiving continuous positive airway pressure(CPAP)therapy,low-flow oxygen inhalation therapy,and no corresponding intervention were assigned to a CPAP group(55 cases),a low-flow oxygen group(60 cases),and a control group(60 cases),respectively.Clinical data were collected,including body mass index,waist circumference,underlying diseases,laboratory test results and color Doppler echocardiography parameters,as well as systolic/diastolic blood pressure,Epworth sleepiness scale(ESS)scores,nocturnal minimum saturation of peripheral oxygen(SpO2),and apnea hypopnea index(AHI)before and after intervention(3 months of treatment).Results Blood pressure control and respiratory parameters in the low-flow oxygen group both improved significantly after oxygen inhalation(both P＜0.05).After 3 months of follow-up,the nocturnal minimum SpO2 in both the low-flow oxygen and CPAP groups increased significantly compared with pre-intervention levels(both P＜0.01).There was statistically significant difference in nocturnal minimum SpO2 after intervention among the three groups(P＜0.01).After pharmacotherapy or intervention,systolic and diastolic blood pressures both decreased significantly in all the three groups compared with pre-intervention levels(all P＜0.05),and post-intervention differences in systolic and diastolic blood pressures among the three groups were statistically significant(all P＜0.05).Compared with baseline,both the low-flow oxygen group and the CPAP group demonstrated significant reduction in ESS score and AHI after the intervention(both P＜0.05).Conclusion Low-flow oxygen inhalation therapy in elderly patients with hypertension and OSAS could partially improve sleep respiratory parameters,increase nocturnal SpO2,and help to increase the compliance rate of blood pressure control,reduce the use of antihypertensive medication and alleviate economic burden.关键词
阻塞性睡眠呼吸暂停综合征/老年/高血压/低流量氧气吸入/持续气道正压通气Key words
obstructive sleep apnoea syndrome/elderly/hypertension/low-flow oxygen inhalation/continuous positive airway pressure分类
临床医学引用本文复制引用
孙侠,崔星钢,仲威,陈广华,戴芝银,袁伟,张朝普..低流量氧气吸入对老年高血压合并阻塞性睡眠呼吸暂停综合征的治疗效果[J].实用心电与临床诊疗,2025,34(5):654-658,664,6.基金项目
镇江市重点研发计划(社会发展)项目(SH2022057) （社会发展）
国家自然科学基金青年基金资助项目(82000261) （82000261）
江苏省重点研发计划项目(BE2021694) （BE2021694）
