实用心电与临床诊疗2025，Vol.34Issue(5)：672-680,9.DOI:10.13308/j.issn.2097-5716.2025.05.009
外周血清Sema3E蛋白水平与急性心肌梗死患者近期死亡的相关性分析
Correlation analysis between peripheral serum Sema3E protein levels and recent death of patients with acute myocardial infarction
摘要
Abstract
Objective To investigate the correlation between peripheral serum Semaphorin 3E(Sema3E)protein levels and recent death of acute myocardial infarction(AMI)patients undergoing emergency percutaneous coronary intervention(PCI).Methods A total of 147 patients treated by PCI were selected,including 67 AMI patients and 80 patients with stable coronary artery disease.All participants were followed up for an average of 6 months(ranging from 3 to 12 months),with all-cause death as the endpoint event.Based on the follow-up outcomes,patients were categorized into a survival group(139 cases)and a death group(8 cases)to analyze the correlation between peripheral serum Sema3E protein levels and their recent death.A subgroup analysis of the 67 AMI patients was performed.These patients were further divided into an AMI survival group(61 cases)and an AMI death group(6 cases)based on the follow-up results.The relationship between Sema3E protein levels and recent death of AMI patients after emergency PCI was explored.Results There were statistically significant differences in age,neutrophil count(NE),hemoglobin,NT-proBNP,and Sema3E protein level between the survival and death groups(all P＜0.05).Multivariate binary Logistic regression analysis identified age(OR=1.140,95％CI 1.028-1.264,P=0.013),NE(OR=1.582,95％CI 1.091-2.296,P=0.016),and serum Sema3E protein level(OR=1.002,95％CI 1.001-1.003,P=0.001)as risk factors for their recent death.Subgroup analysis showed statistically significant differences in age,hemoglobin,total cholesterol,low-density lipoprotein cholesterol,and Sema3E level between the two subgroups(all P＜0.05).Multivariate binary Logistic regression analysis further confirmed serum Sema3E(OR=1.005,95％CI 1.000-1.009,P=0.037)as an independent risk factor for recent death of AMI patients.Conclusion Peripheral serum Sema3E protein levels are correlated with recent death of AMI patients undergoing emergency PCI.关键词
急性心肌梗死/经皮冠状动脉介入/信号素3E/死亡Key words
acute myocardial infarction/percutaneous coronary intervention/Semaphorin 3E/death分类
临床医学引用本文复制引用
尹玉纯,陈天平..外周血清Sema3E蛋白水平与急性心肌梗死患者近期死亡的相关性分析[J].实用心电与临床诊疗,2025,34(5):672-680,9.基金项目
安徽省卫生健康科研项目(AHWJ2022a020) （AHWJ2022a020）
