解放军医学院学报2025，Vol.46Issue(6)：517-522,6.DOI:10.12435/j.issn.2095-5227.25012301
下丘脑/垂体类器官的应用进展
Advances in application of hypothalamic/pituitary organoids
摘要
Abstract
The hypothalamus and pituitary gland are critical components of the endocrine system,and various pathologies,including inflammation,trauma,and developmental anomalies,can result in hypothalamic and pituitary hypoplasia.Nevertheless,investigations concerning the hypothalamus and pituitary gland remain constrained by the paucity of research models possessing suitable characterization properties.Hypothalamic/pituitary organoids,which are micro-organs derived from stem cells cultured in a three-dimensional in vitro environment,exhibit a high degree of congruence with the human hypothalamus and pituitary gland in terms of cellular composition,structural organization,and functional attributes.These organoids hold significant promise for advancing the study of hypothalamic-pituitary disease mechanisms,facilitating drug screening,and contributing to regenerative medicine.This paper aims to review the recent research progress in this field and explore the potential prospective applications of hypothalamic/pituitary organoids and to propose novel approaches for researching hypothalamic/pituitary-related diseases,as well as for the clinical translation of regenerative medicine.关键词
下丘脑/垂体/类器官/干细胞/再生医学Key words
hypothalamus/pituitary/organoids/stem cells/regenerative medicine分类
基础医学引用本文复制引用
肖燕,王胜杰,付蕾,姜得悦,叶玲彤,郭清华..下丘脑/垂体类器官的应用进展[J].解放军医学院学报,2025,46(6):517-522,6.基金项目
国家自然科学基金面上项目(82270824) （82270824）
北京自然科学基金面上项目(7232153) （7232153）
