口腔颌面外科杂志2025，Vol.35Issue(5)：331-342,12.DOI:10.12439/kqhm.1005-4979.2025.05.001
口腔鳞状细胞癌侵袭前缘的代谢特征及其影像标志物的研究进展
Research advances in metabolic profiling and imaging markers of invasive front of OSCC
摘要
Abstract
Oral squamous cell carcinoma(OSCC)is the most common malignant tumor of the head and neck,accounting for 90%of all oral cancers.The disease is prone to recurrence,invasion,and metastasis,leading to a poor prognosis with a five-year survival rate of approximately 50%‒60%.The invasive front of OSCC is a critical region for tumor recurrence and metastasis,characterized by high heterogeneity and aggressiveness.Metabolic reprogramming in this area drives malignant progression and offers potential targets for the development of imaging biomarkers.This review summarizes the metabolic features of the invasive front and their underlying molecular mechanisms,with a focus on how aberrant activation of pathways such as glucose metabolism,lipid metabolism,and amino acid metabolism promotes tumor cell migration,invasion,and immune evasion.Additionally,it discusses the translational applications of metabolic traits at the OSCC invasive front as imaging biomarkers,including the application value of spatial metabolomics,Raman spectroscopy,and positron emission tomography/computed tomography(PET-CT)in predicting tumor boundaries and visualizing metabolic profiles of the invasive front.In the future,integrating multi-omics data with imaging analysis may facilitate the development of clinical translation pathways based on metabolic markers of the invasive front,thereby providing new strategies for precise diagnosis,surgical navigation,and prognosis evaluation of OSCC,and advancing precision diagnosis and treatment for OSCC at the level of small-molecule metabolites.关键词
口腔鳞状细胞癌/侵袭前缘/代谢重编程/空间代谢组/拉曼光谱/正电子发射断层显像-计算机断层扫描Key words
oral squamous cell carcinoma/invasive front/metabolic reprogramming/spatial metabolomics/Raman spectroscopy/positron emission tomography/computed tomography分类
医药卫生引用本文复制引用
刘宇,孔建鲁,朱子羽,章楚晗,杨也牧,周思怡,洪凯哲,俞梦飞,王慧明..口腔鳞状细胞癌侵袭前缘的代谢特征及其影像标志物的研究进展[J].口腔颌面外科杂志,2025,35(5):331-342,12.基金项目
浙江省"尖兵领雁+X"科技计划(2025C02101) （2025C02101）
