兰州大学学报（医学版）2025，Vol.51Issue(9)：18-25,8.DOI:10.13885/j.issn.2097-681X.2025.09.003
光照时长对老年2型糖尿病患者维生素D和血脂的影响
Effects of light duration on vitamin D and blood lipids in elderly patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the effects of different light durations on vitamin D and blood lipids in elderly patients with type 2 diabetes mellitus(T2DM).Methods 395 elderly patients(206 males and 189 females)were selected,their median age being 70.20(67.30,74.40)years old were randomly selected from May 2022 to May 2023 in The First Hospital of Lanzhou University.Their general data,duration of exposure to light,blood lipid profile and 25-hydroxy vitamin D[25(OH)D]level were collected.According to the quar-tile of light duration,the patients were divided into Q1,Q2,Q3 and Q4 groups,and the levels of blood lipids and 25(OH)D in each group were compared.According to the different levels of 25(OH)D,they were divided intoa vitamin D deficiency group and a non-vitamin D deficiency group,and the differences of biochemical indexes in each group were compared.Spearman correlation analysis was used to analyze the correlation between light duration and blood lipids and 25(OH)D levels.Binary Logistic regression was used to analyze the relationship between light duration and vitamin D deficiency.Results The level of 25(OH)D in Q4 group was higher than that in Q1 group and Q2 group(P<0.05),total cholesterol(TC)was lower than that of Q1 group(P<0.05).With the increase of 25(OH)D,the levels of TC and triglyceride(TG)decreased.The dura-tion of illumination was positively correlated with the level of 25(OH)D(rs=0.365,P<0.001),and negatively correlated with TC(rs=-0.244,P<0.001)and TG(rs=-0.229,P<0.001).Binary Logistic regression showed that the risk of vitamin D deficiency decreased in the group with longer exposure time.Conclusion Light can improve the levels of TC,TG and 25(OH)D in elderly patients with T2DM.The levels of TC and TG are increased in patients with vitamin D deficiency.Prolonged exposure to light is associated with a reduced risk of vitamin D deficiency.关键词
日光照射/2型糖尿病/血脂/维生素D/老年人群/光照时长Key words
sun exposure/type 2 diabetes mellitus/blood lipids/vitamin D/elderly patient/duration of expo-sure of light分类
临床医学引用本文复制引用
余燕妮,李郁卓,范锦源,曹蕊,赵彩芳,王佳蕾,路翔,侯丽杰,傅松波..光照时长对老年2型糖尿病患者维生素D和血脂的影响[J].兰州大学学报（医学版）,2025,51(9):18-25,8.基金项目
甘肃省自然科学基金资助项目(22JR5RA914) （22JR5RA914）
兰州市科技发展指导性计划资助项目(2019-ZD-38) （2019-ZD-38）
甘肃省联合科研基金资助项目(23JRRA1490) （23JRRA1490）
