兰州大学学报（医学版）2025，Vol.51Issue(9)：26-30,5.DOI:10.13885/j.issn.2097-681X.2025.09.004
瑞马唑仑—阿芬太尼复合麻醉在儿童埋伏多生牙拔除术中的应用
Clinical study on Remimazolam-Alfentanil combined anesthesia for impacted supernumerary teeth extraction in pediatric patients
摘要
Abstract
Objective To investigate the efficacy and safety of Remimazolam-Alfentanil combined anesthesia in children undergoing extraction of impacted supernumerary teeth.Methods Eighty pediatric patients sched-uled for elective extraction of impacted supernumerary teeth under general anesthesia at The Second Hospital of Lanzhou University were enrolled and randomly assigned to either a Remimazolam-Alfentanil group(Group R)or a Sevoflurane-Alfentanil group(Group S).Heart rate and mean arterial pressure were recorded at the following time points:before anesthesia induction(T1),during laryngeal mask placement(T2),at gingi-val incision(T3),and at the end of surgery(T4).Postoperative recovery time,laryngeal mask removal time,Ramsay sedation scores,incidence of emergence agitation,and total postoperative adverse events were com-pared between the two groups.Results Compared with Group S,Group R exhibited a significantly shorter post-operative recovery time and laryngeal mask removal time(P<0.05).Additionally,Group R demonstrated a lower incidence of emergence agitation,reduced Ramsay sedation scores,decreased rates of postoperative nausea and vomiting,and fewer total adverse events(P<0.05).No statistically significant differences were ob-served between the two groups in postoperative dizziness,pruritus,or changes in mean arterial pressure and heart rate at T1,T2,T3 and T4(P>0.05).Conclusion Remimazolam-Alfentanil combined anesthesia effec-tive-ly shortens postoperative recovery and laryngeal mask removal time in children undergoing extraction of im-pacted supernumerary teeth,while reducing the incidence of emergence agitation and total adverse events.关键词
瑞马唑仑/阿芬太尼/多生牙拔除术/舒适化口腔医疗/儿童麻醉/埋伏多生牙/喉罩通气Key words
Remimazolam/Alfentanil/extraction of supernumerary teeth/comfort-oriented dental care/pediat-ric anesthesia/impacted supernumerary teeth/laryngeal mask airway分类
医药卫生引用本文复制引用
孙莉,录亚鹏,王迎斌,郝伟..瑞马唑仑—阿芬太尼复合麻醉在儿童埋伏多生牙拔除术中的应用[J].兰州大学学报（医学版）,2025,51(9):26-30,5.基金项目
国家卫生健康委医药卫生科技发展研究中心创新药物上市后研究专项(WKZX2024Cx301208) （WKZX2024Cx301208）
兰州大学口腔医院口腔医学科研扶持基金青年项目(lzukqky-2019-y07) （lzukqky-2019-y07）
