兰州大学学报（医学版）2025，Vol.51Issue(9)：56-63,73,9.DOI:10.13885/j.issn.2097-681X.2025.09.008
党参生药学研究进展
Research progress in the pharmacology of Codonopsis Radix
摘要
Abstract
Codonopsis radix(CR)has undergone a historical evolution from being used interchangeably with ginseng to having its botanical origins clearly defined.The Chinese Pharmacopoeia recognizes three official sources:Codonopsis pilosula(Franch.)Nannf.(C.pilosula),Codonopsis pilosula Nannf.var.modesta(Nan-nf.)L.T.Shen(C.pilosula var.modesta),and Codonopsis tangshen Oliv.(C.tangshen).Different places of growth have given rise to distinctive commercial varieties(e.g.,Lu-Dang,Wen-Dang,Banqiao-Dang,and Baitiao-Dang).Modern techniques have advanced the authentication and quality control of CR.Separation and,analysis of,and pharmacological studies on its components such as polysaccharides,saponins,phenylpro-panoids,etc.and triterpenoids in CR have shown that various components and extracts of CR possess effects including immunomodulation,anti-tumor,anti-oxidation,neuroprotection,and blood glucose and lipid low-ering.Significant differences exist among the three botanical sources in terms of geographical distribution,primary chemical constituents,and pharmacological activities:C.pilosula is notable for its characteristic polysaccharides and levan-type oligosaccharides with strong immuno-modulatory and antioxidant effects;C.pilosula var.modesta is distinguished by abundant polysaccharides and triterpenoids and high medicinal value;C.tangshen is characterized by richer phenylpropanoids and organic acids.This review summarized research progress in the areas of historical textual research,geographical distribution,botanical identification,chemical composition,and pharmacological activities of CR,with an emphasis on the heterogeneity in compo-sition and bioactivity among different botanical sources.Based on current evidence,we recommended the implementation of"source-specific management"in clinical applications and quality control,along with the establishment of differentiated quality standards grounded in characteristic chemical markers.Further research should focus on component-activity correlation studies,multi-omics analyses,and multi-center clinical valida-tion to clarify the pharmacodynamic material basis of each botanical source and guide standardized utilization and industrial development.关键词
党参/本草考证/基原辨析/成分差异/药理作用/产区分布Key words
Codonopsis Radix/textual research/botanical differentiation/chemical constituents/pharmacolog-ical activities/geographical distribution分类
中医学引用本文复制引用
王燕萍,陈慧茹,胡芳弟,孟亚男,邵亚洲,徐明星,张艳,王诗怡,董丽,赵婉宁,敬怡辰..党参生药学研究进展[J].兰州大学学报（医学版）,2025,51(9):56-63,73,9.基金项目
甘肃省科技重大专项资助项目(25ZDFA001) （25ZDFA001）
兰州市科技计划资助项目(2024-8-12) （2024-8-12）
甘肃省现代寒旱特色农业药产业技术体系建设专项资金资助项目(GSARS06) （GSARS06）
甘肃省高校青年博士支持资助项目(2025QB-001) （2025QB-001）
兰州大学中央高校基本科研业务费专项资金资助项目(lzujbky-2023-it31) （lzujbky-2023-it31）
兰州市青年科技人才创新资助项目(2024-QN-11) （2024-QN-11）
甘肃省药品科研资助项目——青年科技创新资助项目(2023GSMPA023) （2023GSMPA023）
